Recombinant Human Rhotekin, GST-tagged

• Cat.No.: RTKN-1147H

Specification

• Cat. No.: RTKN-1147H
• Description: Rhotekin (from the Japanese "teki", meaning target) is an effector of the Rho-GTPases that was previously identified in mice. GST-RhotekinRBD is a glutathione S-transferase (GST)-fusion protein of the Rho-binding domain (RBD) of Rhotekin. The N-terminal peptide of Rhotekin contains the amino acids 1-89 comprising the Rho-binding domain between amino acids 7 and 89. The GST-Tag facilitates the protein‘s application in typical GST pull down assays.
• Source: E. coli.
• Usage: For in vitro use only.
• Form: Liquid. Supplied in 50 mM Tris-HCl pH 7.5, 100 mM NaCl and 2 mM DTE.
• Purity: > 95% by SDS-PAGE.
• Storage: Quality guaranteed for 12 months, Store at -80℃. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: RTKN rhotekin [ Homo sapiens ]
• Synonyms: RTKN; rhotekin; B5
• Gene ID: 6242
• mRNA Refseq: NM_001015055
• Protein Refseq: NP_001015055
• MIM: 602288
• UniProt ID: Q9BST9
• Chromosome Location: 2p13.1
• Function: GTP binding; GTP-Rho binding; GTPase inhibitor activity; nucleotide binding; protein binding

Reviews

07/21/2022

They can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.

03/23/2022

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.

12/27/2021

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is RTKN a potential therapeutic target in cancer treatment?

Some studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.

How does RTKN contribute to cellular signaling pathways?

RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.

How is RTKN linked to neurodegenerative diseases?

Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.

Are there any known genetic mutations in the RTKN gene associated with diseases?

Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.

Can RTKN be targeted for drug development?

The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.