Recombinant Human RNF168 Protein (Met1-Lys571), N-His-tagged

• Cat.No.: RNF168-0038H
• Product Overview: Recombinant human RNF168 (Met1-Lys571) was fused with the N-His tag and was expressed in Baculovirus-Insect cells.

Specification

• Source: Baculovirus-Insect cells
• Species: Human
• Tag: N-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 134.42 kDa
• Protein Length: Met1-Lys571
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in 25 mM Hepes (pH 7.4), 500 mM NaCl, 0.1% Chaps, and 1% glycerol or lyophilized from 25 mM Hepes (pH 7.4), 500 mM NaCl, 0.1% Chaps, and 1% glycerol.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: RNF168 ring finger protein 168, E3 ubiquitin protein ligase [ Homo sapiens (human) ]
• Official Symbol: RNF168
• Synonyms: RNF168; ring finger protein 168, E3 ubiquitin protein ligase; ring finger protein 168; E3 ubiquitin-protein ligase RNF168; FLJ35794; FLJ39749
• Gene ID: 165918
• mRNA Refseq: NM_152617
• Protein Refseq: NP_689830
• MIM: 612688
• UniProt ID: Q8IYW5

Reviews

10/04/2020

Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

09/03/2017

This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

06/19/2017

the RNF168 protein offers numerous advantages in trials and research experiments.

Q&As

Are there any current clinical trials involving RNF168 protein?

Clinical trials investigating the potential use of RNF168 as a target for cancer therapy or as a biomarker for cancer prognosis may be underway, but specific details would need to be checked.

How does RNF168 protein contribute to the DNA damage response?

RNF168 plays a role in initiating a signaling cascade that leads to the recruitment of other DNA repair proteins to the site of DNA damage, promoting repair and maintaining genomic stability.

How does RNF168 protein interact with other proteins in the DNA repair pathway?

RNF168 interacts with various proteins involved in the DNA damage response, such as 53BP1 and BRCA1, to coordinate the repair of DNA lesions and maintain genomic stability.

Can mutations in the RNF168 gene be inherited and lead to an increased risk of cancer?

Yes, inherited mutations in the RNF168 gene can increase the risk of developing certain cancers, particularly those associated with DNA damage and repair deficiencies.

Are there any known side effects or toxicities associated with modulating RNF168 activity in cancer therapy?

The potential side effects and toxicities of targeting RNF168 in cancer therapy are still being explored, and would depend on the specific approach and modality used.