Recombinant Human RPE65 Protein, DYKDDDDK-tagged
Cat.No. : | RPE65-01H |
Product Overview : | Recombinant protein from the full-length sequence of homo sapiens RPE65, retinoid isomerohydrolase (RPE65) (NM_000329), with a Whitlow linker and DYKDDDDK tag was expressed in human cells. |
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Description : | This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. |
Source : | Human cells |
Species : | Human |
Tag : | DYKDDDDK |
Molecular Mass : | 70 kDa |
Endotoxin : | < 0.1 ng/μg of protein (< 1 EU/μg) |
Purity : | > 90% by SDS-PAGE gel and Coomassie Blue staining |
Applications : | Antigens, WB, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
Storage Buffer : | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
Gene Name : | RPE65 retinoid isomerohydrolase RPE65 [ Homo sapiens (human) ] |
Official Symbol : | RPE65 |
Synonyms : | RPE65; retinoid isomerohydrolase RPE65; p63; BCO3; LCA2; RP20; rd12; mRPE65; sRPE65; retinoid isomerohydrolase; BCO family, member 3; RBP-binding membrane protein; RPE65, retinoid isomerohydrolase; all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium specific protein 65; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; retinitis pigmentosa 20 (autosomal recessive); retinol isomerase; EC 3.1.1.64; EC 5.3.3.22; ATPase, H+ transporting, lysosomal interacting protein 2; ER-localized type I transmembrane adapter; ER-localized type I transmembrane adaptor; N14F; V-ATPase M8.9 subunit; embryonic liver differentiation factor 10; prorenin receptor; renin/prorenin receptor; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9 |
Gene ID : | 6121 |
mRNA Refseq : | NM_000329 |
Protein Refseq : | NP_000320 |
MIM : | 180069 |
UniProt ID : | Q16518 |
Products Types
◆ Recombinant Protein | ||
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RPE65-4003H | Recombinant Human RPE65 Protein, His (Fc)-Avi-tagged | +Inquiry |
RPE65-02H | Recombinant Human RPE65 Protein, DYKDDDDK-tagged | +Inquiry |
RPE65-01HCL | Recombinant Human RPE65 Over-expression Lysate, Myc/DDK-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGene therapy targeting RPE65 shows promise in treating inherited retinal dystrophies, restoring some visual functions.
RPE65 facilitates the conversion of vitamin A derivatives, essential for the regeneration of visual pigments.
Mutations in RPE65 impact visual acuity and night vision, leading to difficulties in low-light conditions.
Changes in RPE65 may contribute to the progression of age-related macular degeneration, affecting central vision.
RPE65 is involved in the regeneration of photoreceptors and visual pigments, key for maintaining healthy vision.
RPE65 is crucial in the visual cycle, converting vitamin A derivatives necessary for retinal function and vision.
RPE65 deficiency leads to retinal diseases by disrupting the visual cycle, affecting vision from an early age.
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