Recombinant Human RTKN Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RTKN-6216H
• Product Overview: RTKN MS Standard C13 and N15-labeled recombinant protein (NP_149035) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 61.2 kDa
• AA Sequence: MQDRLHILEDLNMLYIRQMALSLED TELQRKLDHEIRMREGACKLLAACS QREQALEATKSLLVCNSRILSYMGE LQRRKEAQVLGKTSRRPSDSGPPAE RSPCRGRVCISDLRIPLMWKDTEYF KNKGDLHRWAVFLLLQLGEHIQDTE MILVDRTLTDISFQSNVLFAEAGPD FELRLELYGACVEEEGALTGGPKRL ATKLSSSLGRSSGRRVRASLDSAGG SGSSPILLPTPVVGGPRYHLLAHTT LTLAAVQDGFRTHDLTLASHEENPA WLPLYGSVCCRLAAQPLCMTQPTAS GTLRVQQAGEMQNWAQVHGVLKGTN LFCYRQPEDADTGEEPLLTIAVNKE TRVRAGELDQALGRPFTLSISNQYG DDEVTHTLQTESREALQSWMEALWQ LFFDMSQWKQCCDEIMKIETPAPRK PPQALAKQGSLYHEMAIEPLDDIAA VTDILTQREGARLETPPPWLAMFTD QPALPNPCSPASVAPAPDWTHPLPW GRPRTFSLDAVPPDHSPRARSVAPL PPQRSPRTRGLCSKGQPRTWLQSPV TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RTKN rhotekin [ Homo sapiens (human) ]
• Official Symbol: RTKN
• Synonyms: RTKN; rhotekin; rhotekin
• Gene ID: 6242
• mRNA Refseq: NM_033046
• Protein Refseq: NP_149035
• MIM: 602288
• UniProt ID: Q9BST9

Reviews

07/21/2022

They can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.

03/23/2022

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.

12/27/2021

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is RTKN a potential therapeutic target in cancer treatment?

Some studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.

How does RTKN contribute to cellular signaling pathways?

RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.

How is RTKN linked to neurodegenerative diseases?

Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.

Are there any known genetic mutations in the RTKN gene associated with diseases?

Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.

Can RTKN be targeted for drug development?

The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.