Recombinant Human SCGB3A2

• Cat.No.: SCGB3A2-7649H
• Product Overview: Recombinant Human UteroglobinRelated Protein 1/UGRP1 is produced by our E. coli expression system.

Specification

• Description: UteroglobinRelated Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amino acid sequence similarity with uteroglobin. UGRP1 is expressed predominantly in the lung and low levels of expression are detected in the thyroid. Expression of UGRP1 in lung epithelial cells is enhanced by IL10 and decreased through the activities of IL9 and IL5. UGRP1 interacts with the macrophage scavenger receptor with collagenous structure which is expressed by alveolar macrophages in the lung. It have suggested that UGRP1 may be involved in inflammation and pathogen clearance in the lung by binding to its receptor.
• Source: E. coli
• Species: Human
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: SCGB3A2 secretoglobin, family 3A, member 2 [ Homo sapiens ]
• Official Symbol: SCGB3A2
• Synonyms: SCGB3A2; secretoglobin, family 3A, member 2; secretoglobin family 3A member 2; LU103; pneumo secretory protein 1; PNSP1; UGRP1; uteroglobin related protein 1; uteroglobin-related protein 1; pnSP-1
• Gene ID: 117156
• mRNA Refseq: NM_054023
• Protein Refseq: NP_473364
• MIM: 606531
• UniProt ID: Q96PL1
• Chromosome Location: 5q32
• Function: binding

Reviews

12/27/2020

Swift and accurate. Critical for our experiments.

11/09/2019

Integral to our research success. Highly recommended.

03/14/2017

Invaluable service. Boosts research productivity.

Q&As

How does SCGB3A2 contribute to lung development and repair?

It plays a role in lung development and repair, contributing to epithelial cell growth and regeneration.

What role does SCGB3A2 play in pulmonary diseases?

SCGB3A2 is implicated in various pulmonary diseases, including asthma and chronic obstructive pulmonary disease (COPD).

What is the primary role of SCGB3A2 in respiratory function?

SCGB3A2, a secretoglobin, is involved in maintaining respiratory tract lining fluid balance and defending against pathogens.

How does SCGB3A2 interact with other proteins in the lung?

SCGB3A2 works with other lung proteins in cellular signaling and immune responses.

How do genetic variations in SCGB3A2 affect lung health?

Genetic variations in SCGB3A2 can influence susceptibility to respiratory ailments and lung function.

What potential therapeutic applications arise from targeting SCGB3A2 in lung diseases?

Targeting SCGB3A2 could offer new treatment strategies for chronic lung diseases.

What is the impact of altered SCGB3A2 activity on respiratory conditions?

Altered SCGB3A2 activity affects lung defense mechanisms, potentially exacerbating respiratory diseases.