Recombinant Human SIRT6 Protein (Met1-Ser355), His tagged

• Cat.No.: SIRT6-2881H
• Product Overview: Recombinant human SIRT6 (Met1-Ser355) protein fused with His tag was expressed in E. coli.

Specification

• Description: Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (+) (NAD (+) dependent enzyme and stress response protein. SIRT6 has several different functions in multiple different molecular pathways related to DNA repair, glycolysis, gluconeogenesis, tumorigenesis, neurodegeneration, cardiac hypertrophic responses, and more. SIRT6 is a main regulator of metabolism and lifespan and its importance has been implicated in the prevention against aging-related diseases. SIRT6 depletion enhanced chemosensitivity of human hepatoma cells by downregulating MDR1 expression through suppressing C/EBPbeta. SIRT6 may serve as a novel target to enhance chemosensitivity in HCC cells.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 39.96 kDa
• Protein Length: Met1-Ser355
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SIRT6 sirtuin 6 [ Homo sapiens (human) ]
• Official Symbol: SIRT6
• Synonyms: SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6
• Gene ID: 51548
• mRNA Refseq: NM_001193285
• Protein Refseq: NP_001180214
• MIM: 606211
• UniProt ID: Q8N6T7

Reviews

07/21/2022

This protein has high yield and good economic benefits.

05/25/2022

Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.

12/13/2021

SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

Q&As

How is SIRT6 involved in DNA repair?

SIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.

What is the nutritional significance of SIRT6?

This proteinexpression of genes related to fat metabolism through deacetylation modifications.

Does SIRT6 have therapeutic potential?

Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.

How does SIRT6 affect nutrient metabolism and energy balance?

SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.

What is the effect of loss of SIRT6 on cells?

Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.

How do the expression levels of SIRT6 differ in different tissues and cells?

There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.