Recombinant Human SIRT6, T7 -tagged

• Cat.No.: SIRT6-28517TH
• Product Overview: Recombinant full length Human SIRT6 with N-terminal proprietary tag, 65 kDa.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
• Conjugation: T7
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Information

• Gene Name: SIRT6 sirtuin 6 [ Homo sapiens ]
• Official Symbol: SIRT6
• Synonyms: SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6
• Gene ID: 51548
• mRNA Refseq: NM_016539
• Protein Refseq: NP_057623
• MIM: 606211
• Uniprot ID: Q8N6T7
• Chromosome Location: 19p13.3
• Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem
• Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific)

Reviews

07/21/2022

This protein has high yield and good economic benefits.

05/25/2022

Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.

12/13/2021

SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

Q&As

How is SIRT6 involved in DNA repair?

SIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.

What is the nutritional significance of SIRT6?

This proteinexpression of genes related to fat metabolism through deacetylation modifications.

Does SIRT6 have therapeutic potential?

Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.

How does SIRT6 affect nutrient metabolism and energy balance?

SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.

What is the effect of loss of SIRT6 on cells?

Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.

How do the expression levels of SIRT6 differ in different tissues and cells?

There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.