Recombinant Human Sirtuin 1, His-tagged
Cat.No. : | SIRT1-4873H |
Product Overview : | Recombinant human SIRT1 (193-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | SIRT1-4873H |
Description : | SIRT1 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT1 being a member of class I. SIRT1 is a stress-response and chromatin-silencing factor. It is an NAD (+)-dependent histone deacetylase involved in various nuclear events such as transcription, DNA replication, and DNA repair. SIRT1 protein binds and deacetylates the p53 protein. |
Applications : | SIRT Assay |
Molecular Weight : | 84 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25 % glycerol. |
Specific Activity : | 2100 RLU/min/mg |
Purity : | > 70 % |
Concentration : | 0.1 ug/ul |
Sequences : | 193-end |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | E2F transcription factor network; Energy Metabolism; FoxO family signaling; HIF-2-alpha transcription factor network; Regulation of Androgen receptor activity; Regulation of retinoblastoma protein; Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III |
Gene Name : | SIRT1 sirtuin 1 [ Homo sapiens ] |
Official Symbol : | SIRT1 |
Synonyms : | SIRT1; sirtuin 1; SIR2L1; NAD-dependent deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; OTTHUMP00000019691; OTTHUMP00000198112; SIR2-like protein 1; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; NAD-dependent deacetylase sirtuin-1 |
Gene ID : | 23411 |
mRNA Refseq : | NM_001142498 |
Protein Refseq : | NP_001135970 |
MIM : | 604479 |
UniProt ID : | Q96EB6 |
Chromosome Location : | 10q21 |
Function : | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; deacetylase activity; histone binding; hydrolase activity; identical protein binding; metal ion binding; p53 binding; protein C-terminus binding; protein domain specific binding; transcription corepressor activity; zinc ion binding; HLH domain binding |
Products Types
◆ Recombinant Protein | ||
SIRT1-30H | Recombinant Human SIRT1 Protein, GST-tagged | +Inquiry |
Sirt1-5883M | Recombinant Mouse Sirt1 Protein, Myc/DDK-tagged | +Inquiry |
SIRT1-11H | Recombinant Human SIRT1 Protein, MYC/DDK-tagged | +Inquiry |
Sirt1-2058R | Recombinant Rat Sirt1 Protein, His-tagged | +Inquiry |
SIRT1-100M | Recombinant Mouse SIRT1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SIRT1-595HCL | Recombinant Human SIRT1 lysate | +Inquiry |
◆ Assay kits | ||
Kit-2025 | SIRT1 FRET-Based Screening Assay Kit | +Inquiry |
Kit-2024 | SIRT1 Direct Fluorescent Screening Assay Kit | +Inquiry |
Kit-2156 | SIRT1 Inhibitor/Activator Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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