| Description : |
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81.1 kDa |
| AA Sequence : |
MAETLEFNDVYQEVKGSMNDGRLRL SRQGIIFKNSKTGKVDNIQAGELTE GIWRRVALGHGLKLLTKNGHVYKYD GFRESEFEKLSDFFKTHYRLELMEK DLCVKGWNWGTVKFGGQLLSFDIGD QPVFEIPLSNVSQCTTGKNEVTLEF HQNDDAEVSLMEVRFYVPPTQEDGV DPVEAFAQNVLSKADVIQATGDAIC IFRELQCLTPRGRYDIRIYPTFLHL HGKTFDYKIPYTTVLRLFLLPHKDQ RQMFFVISLDPPIKQGQTRYHFLIL LFSKDEDISLTLNMNEEEVEKRFEG RLTKNMSGSLYEMVSRVMKALVNRK ITVPGNFQGHSGAQCITCSYKASSG LLYPLERGFIYVHKPPVHIRFDEIS FVNFARGTTTTRSFDFEIETKQGTQ YTFSSIEREEYGKLFDFVNAKKLNI KNRGLKEGMNPSYDEYADSDEDQHD AYLERMKEEGKIREENANDSSDDSG EETDESFNPGEEEEDVAEEFDSNAS ASSSSNEGDSDRDEKKRKQLKKAKM AKDRKSRKKPVEVKKGKDPNAPKRP MSAYMLWLNASREKIKSDHPGISIT DLSKKAGEIWKGMSKEKKEEWDRKA EDARRDYEKAMKEYEGGRGESSKRD KSKKKKKVKVKMEKKSTPSRGSSSK SSSRQLSESFKSKEFVSSDESSSGE NKSKKKRRRSEDSEEEELASTPPSS EDSASGSDETRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
