Recombinant Human TGFB1 protein, His-tagged
Cat.No. : | TGFB1-244H |
Product Overview : | Recombinant Human TGFB1 fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | TGFB1 transforming growth factor, beta 1 [ Homo sapiens ] |
Official Symbol : | TGFB1 |
Synonyms : | TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB; |
Gene ID : | 7040 |
mRNA Refseq : | NM_000660 |
Protein Refseq : | NP_000651 |
MIM : | 190180 |
UniProt ID : | P01137 |
Chromosome Location : | 19q13.1 |
Pathway : | ACE Inhibitor Pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; |
Function : | enzyme binding; eukaryotic cell surface binding; growth factor activity; protein N-terminus binding; protein binding; protein heterodimerization activity; protein homodimerization activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding; |
Products Types
◆ Recombinant Protein | ||
TGFB1-5693R | Recombinant Rat TGFB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Tgfb1-300M | Recombinant Active Mouse TGFB1 Protein, His-tagged(C-ter) | +Inquiry |
Tgfb1-1384R | Recombinant Rat Tgfb1 Protein, His-SUMO-tagged | +Inquiry |
TGFB1-301P | Recombinant Active Pig TGFB1 Protein, His-tagged(C-ter) | +Inquiry |
TGFB1-829B | Recombinant Bovine TGFB1 Protein (279-390 aa), His-tagged | +Inquiry |
◆ Native Protein | ||
TGFB1-21H | Active Native Human TGF- β1 | +Inquiry |
◆ Lysates | ||
TGFB1-803RCL | Recombinant Rat TGFB1 cell lysate | +Inquiry |
TGFB1-001MCL | Recombinant Mouse TGFB1 cell lysate | +Inquiry |
TGFB1-2662HCL | Recombinant Human TGFB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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