| Description : |
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
83.2 kDa |
| AA Sequence : |
MFPQSRHPTPHQAAGQPFKFTIPES LDRIKEEFQFLQAQYHSLKLECEKL ASEKTEMQRHYVMYYEMSYGLNIEM HKQTEIAKRLNTICAQVIPFLSQEH QQQVAQAVERAKQVTMAELNAIIGQ QQLQAQHLSHGHGPPVPLTPHPSGL QPPGIPPLGGSAGLLALSSALSGQS HLAIKDDKKHHDAEHHRDREPGTSN SLLVPDSLRGTDKRRNGPEFSNDIK KRKVDDKDSSHYDSDGDKSDDNLVV DVSNEDPSSPRASPAHSPRENGIDK NRLLKKDASSSPASTASSASSTSLK SKEMSLHEKASTPVLKSSTPTPRSD MPTPGTSATPGLRPGLGKPPAIDPL VNQAAAGLRTPLAVPGPYPAPFGMV PHAGMNGELTSPGAAYASLHNMSPQ MSAAAAAAAVVAYGRSPMVGFDPPP HMRVPTIPPNLAGIPGGKPAYSFHV TADGQMQPVPFPPDALIGPGIPRHA RQINTLNHGEVVCAVTISNPTRHVY TGGKGCVKVWDISHPGNKSPVSQLD CLNRDNYIRSCKLLPDGCTLIVGGE ASTLSIWDLAAPTPRIKAELTSSAP ACYALAISPDSKVCFSCCSDGNIAV WDLHNQTLVRQFQGHTDGASCIDIS NDGTKLWTGGLDNTVRSWDLREGRQ LQQHDFTSQIFSLGYCPTGEWLAVG MESSNVEVLHVNKPDKYQLHLHESC VLSLKFAYCGKWFVSTGKDNLLNAW RTPYGASIFQSKESSSVLSCDISVD DKYIVTGSGDKKATVYEVIYTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
