| Description : |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
89.8 kDa |
| AA Sequence : |
MPHTLWMVWVLGVIISLSKEESSNQ ASLSCDRNGICKGSSGSLNSIPSGL TEAVKSLDLSNNRITYISNSDLQRC VNLQALVLTSNGINTIEEDSFSSLG SLEHLDLSYNYLSNLSSSWFKPLSS LTFLNLLGNPYKTLGETSLFSHLTK LQILRVGNMDTFTKIQRKDFAGLTF LEELEIDASDLQSYEPKSLKSIQNV SHLILHMKQHILLLEIFVDVTSSVE CLELRDTDLDTFHFSELSTGETNSL IKKFTFRNVKITDESLFQVMKLLNQ ISGLLELEFDDCTLNGVGNFRASDN DRVIDPGKVETLTIRRLHIPRFYLF YDLSTLYSLTERVKRITVENSKVFL VPCLLSQHLKSLEYLDLSENLMVEE YLKNSACEDAWPSLQTLILRQNHLA SLEKTGETLLTLKNLTNIDISKNSF HSMPETCQWPEKMKYLNLSSTRIHS VTGCIPKTLEILDVSNNNLNLFSLN LPQLKELYISRNKLMTLPDASLLPM LLVLKISRNAITTFSKEQLDSFHTL KTLEAGGNNFICSCEFLSFTQEQQA LAKVLIDWPANYLCDSPSHVRGQQV QDVRLSVSECHRTALVSGMCCALFL LILLTGVLCHRFHGLWYMKMMWAWL QAKRKPRKAPSRNICYDAFVSYSER DAYWVENLMVQELENFNPPFKLCLH KRDFIPGKWIIDNIIDSIEKSHKTV FVLSENFVKSEWCKYELDFSHFRLF DENNDAAILILLEPIEKKAIPQRFC KLRKIMNTKTYLEWPMDEAQREGFW VNLRAAIKSTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
