Recombinant Human TNFRSF10B, Fc-tagged
Cat.No. : | TNFRSF10B-27023TH |
Product Overview : | Recombinant fragment corresponding to amino acids 52-212 of Human DR5 fused to the Fc portion of Human IgG1; MWt 50 kDa . |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. |
Protein length : | 161 amino acids |
Conjugation : | Fc |
Molecular Weight : | 50.000kDa inclusive of tags |
Source : | HEK 293 cells |
Tissue specificity : | Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, p |
Biological activity : | Blocks Human or Mouse TRAIL activity in a concentration of 1-10μg/ml. Binds to Human and Mouse TRAIL. |
Form : | Lyophilised:Reconstitute with 50μl sterile water to give a final concentration of 1mg/ml. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: PBS |
Storage : | Store at -20°C, Stable for 6 months at -20°C |
Sequence Similarities : | Contains 1 death domain.Contains 3 TNFR-Cys repeats. |
Gene Name : | TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ] |
Official Symbol : | TNFRSF10B |
Synonyms : | TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; |
Gene ID : | 8795 |
mRNA Refseq : | NM_003842 |
Protein Refseq : | NP_003833 |
MIM : | 603612 |
Uniprot ID : | O14763 |
Chromosome Location : | 8p22-p21 |
Pathway : | Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; |
Function : | TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
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Tnfrsf10b-6544M | Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged | +Inquiry |
TNFRSF10B-599H | Active Recombinant Human TNFRSF10B Protein, His-Avi-tagged, Biotinylated | +Inquiry |
TNFRSF10B-51H | Recombinant Human TNFRSF10B protein(Met1-Glu182), hFc-tagged | +Inquiry |
TNFRSF10B-15H | Active Recombinant Human TNFRSF10B Protein | +Inquiry |
◆ Lysates | ||
TNFRSF10B-2829HCL | Recombinant Human TNFRSF10B cell lysate | +Inquiry |
TNFRSF10B-2397MCL | Recombinant Mouse TNFRSF10B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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