| Description : |
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
48.1 kDa |
| AA Sequence : |
MEAMAASTSLPDPGDFDRNVPRICG VCGDRATGFHFNAMTCEGCKGFFRR SMKRKALFTCPFNGDCRITKDNRRH CQACRLKRCVDIGMMKEFILTDEEV QRKREMILKRKEEEALKDSLRPKLS EEQQRIIAILLDAHHKTYDPTYSDF CQFRPPVRVNDGGGSHPSRPNSRHT PSFSGDSSSSCSDHCITSSDMMDSS SFSNLDLSEEDSDDPSVTLELSQLS MLPHLADLVSYSIQKVIGFAKMIPG FRDLTSEDQIVLLKSSAIEVIMLRS NESFTMDDMSWTCGNQDYKYRVSDV TKAGHSLELIEPLIKFQVGLKKLNL HEEEHVLLMAICIVSPDRPGVQDAA LIEAIQDRLSNTLQTYIRCRHPPPG SHLLYAKMIQKLADLRSLNEEHSKQ YRCLSFQPECSMKLTPLVLEVFGNE ISTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
