Recombinant Mouse ABCC12 Protein

• Cat.No.: ABCC12-1099M
• Product Overview: Recombinant Mouse ABCC12 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Abcc12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 [ Mus musculus ]
• Official Symbol: ABCC12
• Gene ID: 244562
• mRNA Refseq: NM_172912.4
• Protein Refseq: NP_766500.3
• UniProt ID: Q80WJ6

Reviews

01/29/2023

Very good attitude in answering questions

12/19/2022

High product quality

08/23/2017

Clear strip

Q&As

Why is it so effect to knock out MRP5 alone?

The closest homologue of MRP5 is MRP9/ABCC12, which does not exist in Caenorhabditis elegans, improving the possibility that MRP9 may compensate MRP5 genetically. MRP5 and MRP9 play a synergistic role in regulating male reproductive function and mitochondrial adequacy.

How to see ABCC12 as a prognostic marker of liver cancer

Relative to the normal liver tissue, mRNA expression of ABCC1/2/3/4/5/6/10 was significantly upregulated (P < .001), and that of ABCC9/11 significantly downregulated (both P < .001), in LIHC.

What is the role of ABCC12 in plants?

It can transport nitrogen, and its expression is up-regulated under low nitrogen conditions

Does ABCC12 related with Idiopathic Chronic Cholestasis？

ABCC12 encodes multidrug resistance-associated protein 9 (MRP9) that belongs to the adenosine 5'-triphosphate-binding cassette transporter C family with unknown function and no previous implication in liver disease. But recent study shows that Immunohistochemistry and Western blotting revealed conserved MRP9 protein expression in the bile ducts in human, mouse, and zebrafish. Zebrafish abcc12-null mutants were prone to cholangiocyte apoptosis, which caused progressive bile duct loss during the juvenile stage.

Does variation in ABCC12 affecting oral baclofen clearance?

Single-nucleotide polymorphisms in ABCC12, SLC28A1, and PPARD were associated with varied responses, which warrants further investigation to determine their effect on spasticity.

Are there many ABCC12 mutants?

Yes,different variants have different function. Four splicing variants encoding putatively short peptides were predominant in ABCC12 gene transcripts. Those splicing variants may represent diverse biological functions of these ABC transporter genes.

Is the expression of ABCC12 similar in mouse and human cells

In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria. However, immunolocalization microscopy and cell fractionation studies with transfected HEK-293 cells and mouse testis show that MRP9/Mrp9 does not localize to mitochondria. In HEK-293 cells, it is predominantly localized in the endoplasmic reticulum.

Can ABCC12 transport anions?

The human MRP/ABCC transporters except MRP9/ABCC12 are all able to transport organic anions, such as drugs conjugated to glutathione, sulphate or glucuronate.

Are the positions of ABCC11 and ABCC12 genes close

Yes,phylogenetic analysis confirmed that ABCC11 and ABCC12 were derived through replication and were most closely related to ABCC5 gene.

In which tissues of human body is ABCC12 generally expressed

The transcripts ABCC12 genes were detected by PCR in various adult human tissues, including liver, lung, and kidney, and also in several fetal tissues.