Recombinant Rat ABCC12 Protein, His (Fc)-Avi-tagged
Cat.No. : | ABCC12-58R |
Product Overview : | Recombinant Rat ABCC12 with His (Fc)-Avi tag was expressed and purified |
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Source : | HEK293 |
Species : | Rat |
Tag : | His (Fc)-Avi |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | ≥85% by SDS-PAGE |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | PBS buffer |
Gene Name : | Abcc12 ATP-binding cassette, subfamily C (CFTR/MRP), member 12 [ Rattus norvegicus ] |
Official Symbol : | ABCC12 |
Gene ID : | 291923 |
mRNA Refseq : | NM_199377.1 |
Protein Refseq : | NP_955409.1 |
UniProt ID : | Q6Y306 |
Products Types
◆ Recombinant Protein | ||
ABCC12-196M | Recombinant Mouse ABCC12 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCC12-403R | Recombinant Rat ABCC12 Protein | +Inquiry |
ABCC12-1099M | Recombinant Mouse ABCC12 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe closest homologue of MRP5 is MRP9/ABCC12, which does not exist in Caenorhabditis elegans, improving the possibility that MRP9 may compensate MRP5 genetically. MRP5 and MRP9 play a synergistic role in regulating male reproductive function and mitochondrial adequacy.
Relative to the normal liver tissue, mRNA expression of ABCC1/2/3/4/5/6/10 was significantly upregulated (P < .001), and that of ABCC9/11 significantly downregulated (both P < .001), in LIHC.
It can transport nitrogen, and its expression is up-regulated under low nitrogen conditions
ABCC12 encodes multidrug resistance-associated protein 9 (MRP9) that belongs to the adenosine 5'-triphosphate-binding cassette transporter C family with unknown function and no previous implication in liver disease. But recent study shows that Immunohistochemistry and Western blotting revealed conserved MRP9 protein expression in the bile ducts in human, mouse, and zebrafish. Zebrafish abcc12-null mutants were prone to cholangiocyte apoptosis, which caused progressive bile duct loss during the juvenile stage.
Single-nucleotide polymorphisms in ABCC12, SLC28A1, and PPARD were associated with varied responses, which warrants further investigation to determine their effect on spasticity.
Yes,different variants have different function. Four splicing variants encoding putatively short peptides were predominant in ABCC12 gene transcripts. Those splicing variants may represent diverse biological functions of these ABC transporter genes.
In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria. However, immunolocalization microscopy and cell fractionation studies with transfected HEK-293 cells and mouse testis show that MRP9/Mrp9 does not localize to mitochondria. In HEK-293 cells, it is predominantly localized in the endoplasmic reticulum.
The human MRP/ABCC transporters except MRP9/ABCC12 are all able to transport organic anions, such as drugs conjugated to glutathione, sulphate or glucuronate.
Yes,phylogenetic analysis confirmed that ABCC11 and ABCC12 were derived through replication and were most closely related to ABCC5 gene.
The transcripts ABCC12 genes were detected by PCR in various adult human tissues, including liver, lung, and kidney, and also in several fetal tissues.
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