Recombinant Mouse Abt1 Protein, Myc/DDK-tagged

• Cat.No.: Abt1-1482M
• Product Overview: Purified recombinant protein of mouse full-length activator of basal transcription 1 (Abt1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 30.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Abt1 activator of basal transcription 1 [ Mus musculus (house mouse) ]
• Official Symbol: Abt1
• Synonyms: Abt1; activator of basal transcription 1; activator of basal transcription 1
• Gene ID: 30946
• mRNA Refseq: NM_013924
• Protein Refseq: NP_038952
• UniProt ID: Q9QYL7

Reviews

03/09/2019

Performs excellently in ELISA experiments.

07/04/2017

Very stable and reliable in Western Blot experiments.

11/19/2016

Shows outstanding performance in immunohistochemistry experiments.

Q&As

What is the function of the domains in the ABT1 protein structure?

ABT1 protein structure contains a DNA-binding domain, an activation domain, and a dimerization domain with specific functions.

What is the effect of ABT1 on embryonic development?

ABT1 is essential for embryonic development, and its knockout results in embryonic lethality in mice. It plays a role in the differentiation of various embryonic cell types.

What is the role of ABT1 in cell differentiation?

ABT1 has been shown to play a crucial role in cell differentiation by regulating the expression of genes involved in this process.

What is the crystal structure of the Activator of Basal Transcription 1 (ABT1) protein?

ABT1 protein crystal structure is not experimentally determined yet, but computational modeling studies have predicted it based on homology to other transcription factors.

What is the role of ABT1 in the nervous system?

ABT1 has been shown to be involved in the development and function of the nervous system, with studies suggesting that it may play a role in synaptic plasticity and learning and memory.

What is the function of ABT1 in the immune system?

ABT1 has been shown to regulate the expression of genes involved in the immune response and plays a role in the development and function of immune cells.

What is the effect of ABT1 knockdown or overexpression on cellular processes?

ABT1 knockdown or overexpression has been shown to have various effects on cellular processes, including cell proliferation, differentiation, and apoptosis.

How is the expression of the Activator of Basal Transcription 1 (ABT1) gene regulated?

The expression of the ABT1 gene is regulated by several factors, including transcription factors and epigenetic modifications such as DNA methylation and histone modifications.

Does ABT1 play a role in cancer development?

Yes, ABT1 has been implicated in cancer development, with studies showing that its expression is dysregulated in various types of cancer.

Are there any known mutations in the ABT1 gene that affect protein structure or function?

There are currently no known mutations in the ABT1 gene that affect protein structure or function. Further studies are needed to investigate potential mutations and their effects.