Recombinant Mouse ACTG2 Protein Pre-coupled Magnetic Beads

• Cat.No.: ACTG2-285M-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Mouse
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Actg2 actin, gamma 2, smooth muscle, enteric [ Mus musculus ]
• Official Symbol: ACTG2
• Gene ID: 11468
• mRNA Refseq: NM_009610.2
• Protein Refseq: NP_033740.2
• UniProt ID: P63268

Reviews

07/20/2022

Our experiments consistently demonstrate that the protein product effectively promotes cell proliferation and growth.

01/17/2020

The purity of the protein is evident from the absence of any contaminants, ensuring reliable and accurate results.

01/29/2019

We have used the protein product across multiple experiments, and its performance has remained consistent throughout.

04/07/2017

The shipping process was expedited, ensuring timely delivery of the product to our laboratory.

03/21/2016

The company's customer support team has been extremely helpful, promptly addressing any technical or scientific inquiries.

Q&As

What role does ACTG2 play in hepatocellular carcinoma (HCC)?

ACTG2 has been found to have a critical role in HCC tumor metastasis.

Can ACTG2 expression be regulated by other factors?

Yes, ACTG2 expression can be regulated by various signaling pathways and transcription factors specific to smooth muscle cells.

What effect does ACTG2 have on cell growth?

ACTG2 inhibits cell growth in vitro.

Is ACTG2 expression limited to smooth muscle tissues?

While ACTG2 is primarily expressed in smooth muscle tissues, low levels of expression have also been detected in other tissues, suggesting potential additional functions.

What is the function of the ACTG2 gene?

The ACTG2 gene encodes the protein actin gamma-2, which is involved in muscle contraction and smooth muscle function.

Are there any known genetic disorders associated with ACTG2 mutations?

Yes, mutations in the ACTG2 gene have been linked to a group of rare disorders called visceral myopathy, which affect the function of smooth muscles in the gastrointestinal tract.

Are there any known interacting proteins or partners of ACTG2?

ACTG2 can interact with various proteins involved in cytoskeletal organization and muscle contraction, such as myosin and other actin-binding proteins

How is ACTG2 involved in muscle contraction?

ACTG2 is an essential component of the actin cytoskeleton in smooth muscle cells, providing structural support and facilitating the contraction of these muscles.

Is ACTG2 considered a potential target for HCC treatment?

Yes, ACTG2 is regarded as a novel target for the treatment of HCC.

How does the discovery of ACTG2's role impact HCC research?

The discovery of ACTG2's role provides valuable insights for further understanding and potentially treating HCC.

Which tumors express ACTG2?

ACTG2 is expressed in a fraction of small intestine neuroendocrine tumors (SI-NETs).

What regulates the expression of ACTG2?

miR-145 positively regulates the expression of ACTG2.

Are there any therapeutic implications related to ACTG2?

Given its role in smooth muscle function, ACTG2 may hold therapeutic potential for conditions involving smooth muscle dysfunction, such as gastrointestinal motility disorders.

Where is ACTG2 primarily expressed in the human body?

ACTG2 is primarily expressed in smooth muscle tissues, including the smooth muscle cells of the gastrointestinal tract, blood vessels, and uterus.

What are the symptoms of ACTG2-related visceral myopathy?

Symptoms of ACTG2-related visceral myopathy can include gastrointestinal dysmotility, constipation, difficulty swallowing, and other digestive issues.

What is the structure of the ACTG2 protein?

The ACTG2 protein belongs to the actin family and has a globular structure composed of multiple subunits that form filaments.

Can targeting ACTG2 have therapeutic implications for HCC patients?

Yes, targeting ACTG2 holds promise as a potential therapeutic approach for treating HCC.

How can the findings regarding ACTG2 and miR-145 be utilized in therapeutic strategies?

The findings suggest potential therapeutic strategies for small intestine neuroendocrine tumors (SI-NETs) based on ACTG2 and its regulation by miR-145.