Recombinant Mouse Afap1l2 Protein, Myc/DDK-tagged

• Cat.No.: Afap1l2-1547M
• Product Overview: Purified recombinant protein of mouse full-length actin filament associated protein 1-like 2 (Afap1l2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 92.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Afap1l2 actin filament associated protein 1-like 2 [ Mus musculus (house mouse) ]
• Official Symbol: Afap1l2
• Synonyms: Afap1l2; actin filament associated protein 1-like 2; C86904; AU041783; mKIAA1914; actin filament-associated protein 1-like 2; AFAP1-like protein 2
• Gene ID: 226250
• mRNA Refseq: NM_001177797
• Protein Refseq: NP_001171268
• UniProt ID: Q5DTU0

Reviews

12/07/2022

Probing protein-protein interactions in DNA damage response for genome stability.

11/23/2022

Deciphering protein-protein interactions in intracellular trafficking for cellular transport.

12/30/2021

Elucidating protein-protein interactions in cytoskeletal dynamics for cell motility.

Q&As

How does dysregulation or dysfunction of AFAP1L2 protein affect cellular homeostasis, molecular signaling networks, or disease progression?

Dysregulation or dysfunction of AFAP1L2 protein can disrupt cellular homeostasis, perturb molecular signaling networks, and contribute to disease progression.

What experimental techniques or assays have been used to study the functional significance of AFAP1L2 protein, such as immunoprecipitation, live-cell imaging, or functional assays?

Various experimental techniques or assays, such as immunoprecipitation, live-cell imaging, or functional assays, have been used to study the functional significance of AFAP1L2 protein.

Are there any genetic variations or mutations in the gene encoding AFAP1L2 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility?

Genetic variations or mutations in the gene encoding AFAP1L2 protein may impact its expression or function, influencing cellular processes or disease susceptibility.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AFAP1L2 protein?

Post-translational modifications and regulatory mechanisms modulate the activity or stability of AFAP1L2 protein.

Does AFAP1L2 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions?

AFAP1L2 protein interacts with specific molecules or forms protein complexes, which have functional implications in cellular processes.

What is the role of AFAP1L2 protein in cellular processes such as actin cytoskeleton dynamics, cell migration, or cell adhesion, and how can its function be investigated experimentally?

AFAP1L2 protein plays a role in cellular processes such as actin cytoskeleton dynamics, cell migration, or cell adhesion, and its function can be investigated using techniques like siRNA knockdown or overexpression studies.

What is the subcellular localization of AFAP1L2 protein, and how can it be experimentally determined?

The subcellular localization of AFAP1L2 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.

Can AFAP1L2 protein be targeted or manipulated to modulate cellular processes, and what are the potential implications for therapeutic interventions?

AFAP1L2 protein holds potential as a target for modulating cellular processes, and further research is needed to explore its therapeutic implications and potential interventions.

How is the expression of AFAP1L2 protein regulated, and what factors or signaling pathways control its expression?

The expression of AFAP1L2 protein is regulated by specific factors and signaling pathways.

How does AFAP1L2 protein contribute to disease development or pathophysiological conditions, and what are the underlying molecular mechanisms?

AFAP1L2 protein contributes to disease development or pathophysiological conditions, and the underlying molecular mechanisms are currently being investigated.