Recombinant Mouse AKNA Protein, His (Fc)-Avi-tagged

• Cat.No.: AKNA-434M
• Product Overview: Recombinant Mouse AKNA with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Akna AT-hook transcription factor [ Mus musculus ]
• Official Symbol: AKNA
• Gene ID: 100182
• mRNA Refseq: NM_001045514.2
• Protein Refseq: NP_001038979.1
• UniProt ID: Q80VW7

Reviews

11/03/2022

Its exceptional purity and reliability guarantee reliable and consistent results throughout my research endeavors.

07/11/2021

With these advantages, I am confident that my research will yield fruitful outcomes.

10/11/2019

Alongside the manufacturer's outstanding technical support, I am equipped with a reliable protein and the assurance of effective problem-solving.

08/05/2018

By choosing the AKIRIN2 protein, I can confidently proceed with my experiments knowing that I have a top-notch protein at my disposal.

Q&As

Are there any therapeutic implications of targeting AKNA protein?

Targeting AKNA protein could have therapeutic implications in various diseases. In autoimmune disorders, modulating the activity of AKNA or its downstream signaling pathways could potentially alleviate the immune dysregulation and reduce disease severity.

Can targeting AKNA protein have therapeutic implications?

Targeting AKNA protein could have therapeutic implications, particularly in immune-related diseases or conditions characterized by abnormal gene expression patterns. Modulating AKNA activity or its interactions with other proteins could potentially regulate immune responses, inflammation, or even embryonic development. However, the development of specific AKNA-targeted therapies would require a deeper understanding of its function and its precise role in disease processes.

Are there any animal models available to study AKNA protein?

Yes, animal models, particularly mice, have been used to study the function of AKNA protein. Knockout mouse models lacking AKNA have been generated, allowing researchers to investigate its role in immune responses, development, and disease. These models have provided valuable insights into the physiological functions of AKNA protein.

Are there any ongoing research studies or clinical trials specifically focused on AKNA protein?

As of now, there are limited ongoing research studies or clinical trials specifically focused on AKNA protein. The study of AKNA is still relatively new, and its functions and mechanisms are still being elucidated. However, research into AKNA and its involvement in various diseases is ongoing.

Can dysregulation of AKNA protein lead to disease?

Dysregulation of AKNA protein has been associated with several diseases. In autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, alterations in AKNA expression or function have been reported. These changes can contribute to the dysregulation of immune responses and the development of autoimmunity.

Is AKNA protein expressed in all cell types?

The expression of AKNA protein is not uniform in all cell types. It exhibits tissue-specific and cell-type-specific expression patterns. It has been found to be highly expressed in immune cells, particularly in B cells and T cells, where it plays a crucial role in immune system development and function. AKNA expression is also seen in other cell types, including epithelial cells, neuronal cells, and embryonic stem cells.

Are there any known interactions of AKNA protein with other molecules or proteins?

Yes, AKNA protein can interact with various molecules and proteins to carry out its functions. It has been shown to interact with other transcription factors, including NF-κB and IRF (interferon regulatory factors), to modulate gene expression. AKNA can also interact with co-regulators such as histone acetyltransferases and chromatin remodeling complexes, potentially influencing gene accessibility and transcriptional activity.

Does AKNA protein have any post-translational modifications?

Yes, AKNA protein can undergo post-translational modifications, which can influence its function and activity. Phosphorylation of AKNA has been reported, and it has been shown to affect its subcellular localization and DNA-binding activity. Other modifications, such as acetylation or methylation, have not been extensively studied but may also occur.

Does AKNA play a role in other biological processes?

Yes, apart from its role in the immune system, AKNA has been implicated in other biological processes. It is involved in embryonic development, particularly in the formation and patterning of various tissues and organs. AKNA has been shown to be essential for proper limb development, neural tube closure, and heart development in mouse models.

Is AKNA protein associated with any diseases or disorders?

While AKNA protein has not been directly linked to any specific diseases, it has been implicated in immune-related processes and inflammation. Dysregulation of AKNA activity could potentially contribute to the development or progression of autoimmune diseases, infectious diseases, or inflammatory disorders. However, more research is needed to fully understand the role of AKNA in disease pathogenesis.

What are the specific functions of AKNA protein in immune cells?

In immune cells, AKNA protein is involved in various functions, primarily in B cells and T cells. It plays a crucial role in the development and maturation of B cells, contributing to their differentiation into mature antibody-secreting cells. AKNA is necessary for class-switch recombination, a process that allows B cells to produce different types of antibodies to combat different pathogens.