AKNA
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Official Full Name
AT-hook transcription factor
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Synonyms
AKNA; AT-hook transcription factor; AT-hook-containing transcription factor; KIAA1968; FLJ33184; MGC116630; mKIAA1968; OTTHUMP00000021973; OTTHUMP00000021974; RP23-340H1.6; AI597013; AKNA transcript F2; AT hook containing transcription factor; AT hook transcription factor; AT hook transcription factor AKNA; FLJ31001; OTTMUSP00000015051; RP11 82I1.4; AT-hook transcription factor AKNA; RP11-82I1.4;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AKNA-407H | Recombinant Human AKNA Protein, GST-tagged | Wheat Germ | GST | ||
Mouse | AKNA-1487M | Recombinant Mouse AKNA Protein | Mammalian Cell | His | ||
Mouse | AKNA-434M-B | Recombinant Mouse AKNA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | AKNA-434M | Recombinant Mouse AKNA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- AKNA Related Articles
AKNA involved in several pathways and played different roles in them. We selected most pathways AKNA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AKNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AKNA has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKNA itself. We selected most functions AKNA had, and list some proteins which have the same functions with AKNA. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | E2F4;NR5A1;ZNF565;ZNF497;HIF1AL;HOXA11A;POLR1C;ZKSCAN3;DLX2B |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | ETV4;ETV1;FIGLA;JUND;NR1H2;TFAP2E;NR3C1;TCF4;RFX4 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOSL1;ZFP639;CREB3L1;MEOX1;EGR2;SFPI1;NKX2;GABPA;CTCFL |
AKNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKNA here. Most of them are supplied by our site. Hope this information will be useful for your research of AKNA.
- Q&As
- Reviews
Q&As (11)
Ask a questionTargeting AKNA protein could have therapeutic implications in various diseases. In autoimmune disorders, modulating the activity of AKNA or its downstream signaling pathways could potentially alleviate the immune dysregulation and reduce disease severity.
Targeting AKNA protein could have therapeutic implications, particularly in immune-related diseases or conditions characterized by abnormal gene expression patterns. Modulating AKNA activity or its interactions with other proteins could potentially regulate immune responses, inflammation, or even embryonic development. However, the development of specific AKNA-targeted therapies would require a deeper understanding of its function and its precise role in disease processes.
Yes, animal models, particularly mice, have been used to study the function of AKNA protein. Knockout mouse models lacking AKNA have been generated, allowing researchers to investigate its role in immune responses, development, and disease. These models have provided valuable insights into the physiological functions of AKNA protein.
As of now, there are limited ongoing research studies or clinical trials specifically focused on AKNA protein. The study of AKNA is still relatively new, and its functions and mechanisms are still being elucidated. However, research into AKNA and its involvement in various diseases is ongoing.
Dysregulation of AKNA protein has been associated with several diseases. In autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, alterations in AKNA expression or function have been reported. These changes can contribute to the dysregulation of immune responses and the development of autoimmunity.
The expression of AKNA protein is not uniform in all cell types. It exhibits tissue-specific and cell-type-specific expression patterns. It has been found to be highly expressed in immune cells, particularly in B cells and T cells, where it plays a crucial role in immune system development and function. AKNA expression is also seen in other cell types, including epithelial cells, neuronal cells, and embryonic stem cells.
Yes, AKNA protein can interact with various molecules and proteins to carry out its functions. It has been shown to interact with other transcription factors, including NF-κB and IRF (interferon regulatory factors), to modulate gene expression. AKNA can also interact with co-regulators such as histone acetyltransferases and chromatin remodeling complexes, potentially influencing gene accessibility and transcriptional activity.
Yes, AKNA protein can undergo post-translational modifications, which can influence its function and activity. Phosphorylation of AKNA has been reported, and it has been shown to affect its subcellular localization and DNA-binding activity. Other modifications, such as acetylation or methylation, have not been extensively studied but may also occur.
Yes, apart from its role in the immune system, AKNA has been implicated in other biological processes. It is involved in embryonic development, particularly in the formation and patterning of various tissues and organs. AKNA has been shown to be essential for proper limb development, neural tube closure, and heart development in mouse models.
While AKNA protein has not been directly linked to any specific diseases, it has been implicated in immune-related processes and inflammation. Dysregulation of AKNA activity could potentially contribute to the development or progression of autoimmune diseases, infectious diseases, or inflammatory disorders. However, more research is needed to fully understand the role of AKNA in disease pathogenesis.
In immune cells, AKNA protein is involved in various functions, primarily in B cells and T cells. It plays a crucial role in the development and maturation of B cells, contributing to their differentiation into mature antibody-secreting cells. AKNA is necessary for class-switch recombination, a process that allows B cells to produce different types of antibodies to combat different pathogens.
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