Recombinant Mouse ALOX12E Protein, His (Fc)-Avi-tagged

• Cat.No.: ALOX12E-482M
• Product Overview: Recombinant Mouse ALOX12E with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Alox12e arachidonate lipoxygenase, epidermal [ Mus musculus ]
• Official Symbol: ALOX12E
• Gene ID: 11685
• mRNA Refseq: NM_145684.1
• Protein Refseq: NP_663717.1
• UniProt ID: P55249

Reviews

03/19/2021

When desensitize specific allergens, ALOX12E has a strong potential.

03/03/2020

ALOX12E showed good compatibility and stability with various excipients.

11/10/2019

The pharmacodynamic parameters of ALOX12E were better.

Q&As

What are the detection methods for ALOX12E?

The detection methods of ALOX12E include immunohistochemistry, real-time fluorescence quantitative PCR, etc.

What is the role of ALOX12E in the effect of estrogen on the skin?

ALOX12E may be involved in the regulation of the effects of estrogen on the skin, but the specific role needs to be studied.

What is the function of ALOX12E?

ALOX12E catalyzes the oxidation of arachidonic acid in epidermal cells to form 12-hydroxyarachidonic acid, thus participating in the keratinization process and skin barrier formation.

What diseases is overexpression of ALOX12E associated with?

Overexpression of ALOX12E is associated with psoriasis, atopic dermatitis, and lupus erythematosus.

What is the role of ALOX12E in immune response?

This protein may be involved in the regulation of skin immune response, but its specific role needs further study.

Which chromosome is the ALOX12E gene located on?

The gene for ALOX12E is located on human chromosome 17.

How does the consequences of a point mutation in ALOX12E?

Point mutations in ALOX12E can lead to skin disorders such as abnormal keratosis and ichthyosis.

Under what circumstances is ALOX12E activated?

It may be activated in response to cell stimulation, such as trauma.

What are the inhibitors of ALOX12E?

Inhibitors of ALOX12E include arabidopsis, procainamide, etc.

What is the signaling pathway of ALOX12E?

The ALOX12E signaling pathway is mainly realized through the MAPK signaling pathway.

Which role of ALOX12E in apoptosis?

ALOX12E may play an anti-apoptotic role in cell apoptosis.

Is there a relationship between ALOX12E and skin cancer?

ALOX12E has been linked to skin cancer, and its inhibitors can be used to treat skin cancer.

Which diseases are ALOX12E abnormalities associated with?

Abnormalities in ALOX12E have been linked to conditions such as psoriasis, atopic dermatitis and dry skin.

In which tissues is ALOX12E expressed?

ALOX12E is mainly expressed in the skin and cornea.

What is the regulation of ALOX12E expression?

The expression of ALOX12E is affected by many factors such as extracellular calcium ion concentration, extracellular oxygen partial pressure, and cytokines.