Recombinant Mouse Als2cl Protein, Myc/DDK-tagged

• Cat.No.: Als2cl-1606M
• Product Overview: Purified recombinant protein of mouse full-length ALS2 C-terminal like (Als2cl), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 108.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Als2cl ALS2 C-terminal like [ Mus musculus (house mouse) ]
• Official Symbol: Als2cl
• Synonyms: ALS2CL; ALS2 C-terminal like; ALS2 C-terminal-like protein; mFLJ00189 protein; 79H19D; 79H19E; BC022645; mRn.49018; D930044G19Rik
• Gene ID: 235633
• mRNA Refseq: NM_001146060
• Protein Refseq: NP_001139532
• UniProt ID: Q60I26

Reviews

11/09/2022

Comprehensive technical support from the supplier.

05/21/2020

Compatible with high-throughput screening platforms.

06/27/2018

Cost-effective solution for protein analysis.

Q&As

What are the functional domains or motifs present in ALS2CL, and how do they contribute to its molecular functions?

ALS2CL contains conserved domains, such as coiled-coil domains, which are involved in protein-protein interactions and may contribute to its cellular roles.

Can ALS2CL enzymatic activities be characterized, and what are their potential substrates or targets?

The enzymatic activities of ALS2CL are not well-characterized, and further studies are required to determine its potential substrates and targets.

Can therapeutic interventions targeting ALS2CL or its associated pathways offer potential strategies for treating neurodegenerative disorders or other related conditions?

Targeting ALS2CL or its associated pathways could hold potential therapeutic strategies for neurodegenerative disorders, aiming to restore proper membrane trafficking, neuronal connectivity, or synaptic function.

How does ALS2CL contribute to neuronal function or neuronal development, and are there any specific pathways or processes affected by ALS2CL?

ALS2CL is involved in neuronal processes, such as neurite outgrowth and synaptic development, potentially through interactions with cytoskeletal components and signaling molecules.

Are there any genetic variations or mutations in ALS2CL associated with neurodegenerative diseases or other pathological conditions?

There is limited evidence linking genetic variations or mutations in ALS2CL to neurodegenerative diseases or pathological conditions.

Does ALS2CL interact with other proteins or form complexes involved in cellular processes or signaling pathways?

ALS2CL may interact with proteins involved in vesicle trafficking, protein sorting, or ER-Golgi transport, forming complexes critical for its functions.

What is the tissue-specific expression pattern of ALS2CL, and are there any factors that regulate its expression levels?

ALS2CL exhibits a tissue-specific expression pattern, with higher expression levels observed in certain brain regions and neural tissues.

Does ALS2CL play a role in cellular processes such as vesicle trafficking, membrane dynamics, or cytoskeletal organization?

ALS2CL is implicated in membrane trafficking events, including vesicle formation and fusion processes, contributing to cellular membrane dynamics.

Can ALS2CL expression or activity be modulated by post-translational modifications, and how do they impact its cellular functions?

Post-translational modifications, such as phosphorylation or acetylation, may regulate ALS2CL activity, stability, or its interactions with other proteins.

What are the subcellular localization and distribution patterns of ALS2CL within cells, and does it exhibit any specific organelle associations?

ALS2CL localizes to both the cytoplasm and cellular membranes, including the endoplasmic reticulum (ER) and Golgi apparatus.