Recombinant Mouse ANK2 Protein

• Cat.No.: ANK2-1645M
• Product Overview: Recombinant Mouse ANK2 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Ank2 ankyrin 2, brain [ Mus musculus ]
• Official Symbol: ANK2
• Gene ID: 109676
• mRNA Refseq: NM_001034168.1
• Protein Refseq: NP_001029340.1
• UniProt ID: Q8C8R3

Reviews

06/20/2022

In addition to the advantages of ANK2 protein itself, the manufacturer can play a crucial role in supporting the research efforts.

05/25/2022

This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

09/18/2019

They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

12/06/2017

the manufacturer's technical expertise can be advantageous to researchers.

Q&As

Are there any other known functions of ANK2?

Yes, besides its role in cell membrane organization and neuronal function, ANK2 has been implicated in other cellular processes. It is involved in the regulation of cell adhesion, cell migration, and intracellular signaling pathways. ANK2 also interacts with various proteins, including those involved in the immune response, embryonic development, and cancer progression.

Are there any drugs targeting ANK2?

Currently, there are no specific drugs designed to target ANK2. However, ongoing research aims to identify compounds that can modulate the function of ANK2 or interact with compromised ANK2 isoforms to alleviate symptoms associated with ANK2 mutations or related disorders.

Are there any animal models used to study ANK2-related disorders?

Yes, animal models, such as mice, have been generated to study ANK2-related disorders and investigate the consequences of ANK2 mutations. These models allow researchers to understand the molecular and physiological impact of ANK2 dysfunction and test potential therapeutic interventions.

Can ANK2 mutations lead to heart disorders?

Yes, ANK2 mutations have been associated with various cardiac disorders, including long QT syndrome, Brugada syndrome, and arrhythmogenic right ventricular cardiomyopathy (ARVC). These mutations can disrupt the normal function of ANK2 in cell membrane organization and ion channel anchoring, leading to abnormal electrical signaling in the heart.

How are ANK2 mutations diagnosed?

Diagnosis of ANK2-related disorders typically involves genetic testing, where the ANK2 gene is sequenced to identify any mutations. Additionally, cardiac evaluations including electrocardiograms (ECGs) and other tests can aid in diagnosing cardiac arrhythmias.

Is ANK2 expression tissue-specific?

Some isoforms of ANK2 exhibit tissue-specific expression patterns. For example, the ANK2 isoform containing exon B is primarily found in the heart, while others may have wide-ranging distribution in different tissues. The specific isoforms expressed in a particular tissue depend on developmental stages and cellular requirements.

What disorders are associated with ANK2 mutations?

Mutations in the ANK2 gene have been linked to certain cardiac arrhythmias, such as Long QT syndrome and atrial fibrillation. These mutations can disrupt the proper localization and function of ion channels involved in regulating the heart's electrical activity.

What are the different isoforms of ANK2?

The ANK2 gene can produce multiple isoforms due to alternative splicing, resulting in proteins of different lengths and functions. Some isoforms of ANK2 are primarily found in the heart, while others are present in various other tissues.

Can ANK2 mutations cause psychiatric disorders?

Some studies have suggested a potential link between certain ANK2 mutations and psychiatric disorders, including bipolar disorder and schizophrenia. However, the exact mechanism by which ANK2 mutations predispose individuals to these conditions is not fully understood and requires further investigation.

Can ANK2 mutations be inherited?

Yes, ANK2 mutations can be inherited in an autosomal dominant manner, meaning that an affected individual has a 50% chance of passing the mutation onto their offspring. However, spontaneous mutations can also occur, leading to ANK2-related disorders without any family history.

Can variations in ANK2 contribute to cardiac susceptibility?

Studies have shown that certain genetic variations or polymorphisms in the ANK2 gene may influence an individual's susceptibility to arrhythmias and cardiac disorders. These variations might affect the expression or function of ANK2, thereby increasing the risk of abnormal cardiac rhythms.

Can ANK2 mutations be treated?

Treatment options for ANK2-related disorders usually focus on managing symptoms and preventing arrhythmias. This can involve medications to regulate heart rhythm, lifestyle modifications, and in some cases, cardiac devices like pacemakers or implantable defibrillators.

What are the consequences of ANK2 dysfunction in the brain?

Dysfunction of ANK2 in the brain can result in neuronal hyperexcitability and impaired neurotransmission. This can contribute to neurological disorders such as epilepsy, autism spectrum disorders, and intellectual disabilities. Additionally, ANK2 mutations have been linked to increased susceptibility to neurodegenerative diseases like Alzheimer's and Parkinson's.