ANK2
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Official Full Name
Ankyrin 2, Neuronal
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Overview
Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. -
Synonyms
ANK2; ankyrin 2, neuronal; LQT4; ANK-2; brank-2; ankyrin-2; ankyrin B; ankyrin, brain; non-erythroid ankyrin; ankyrin-2, non-erythrocytic; Brain ankyrin; long (electrocardiographic) QT syn-drome 4; DKFZp686M09125; FLJ38277; OTTHUMP00000163833; OTTHUMP00000163834; OTTHUMP00000220392; OTTHUMP00000220393; OTTHUMP00000220397; OTTHUMP00000220398; OTTHUMP00000231464; ankyrin, nonerythroid; Ankyrin-B;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- HEK293T
- Mammalian Cell
- C
- Myc
- DDK
- His
- His (Fc)
- Avi
- MYC
- Myc|DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANK2-103H | Recombinant Human ANK2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Human | ANK2-2077H | Recombinant Human ANK2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Mouse | ANK2-1645M | Recombinant Mouse ANK2 Protein | Mammalian Cell | His | ||
Mouse | Ank2-429M | Recombinant Mouse Ank2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | ANK2-533M-B | Recombinant Mouse ANK2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ANK2-533M | Recombinant Mouse ANK2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ANK2 involved in several pathways and played different roles in them. We selected most pathways ANK2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Proteoglycans in cancer | HSPB2;GPC3;FZD3;PIK3CB;PIK3R3;PLAU;DDX5;HOXD10;PPP1R12C |
ANK2 has several biochemical functions, for example, ATPase binding, ion channel binding, potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANK2 itself. We selected most functions ANK2 had, and list some proteins which have the same functions with ANK2. You can find most of the proteins on our site.
Function | Related Protein |
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ATPase binding | RALB;PKD2;PEX19;EZR;ATP6V0A4;CHRNA7;NHP2L1;TOR1AIP1;ATXN3 |
ion channel binding | FKBP1A;SLC8A1;RIMS1;DIAP1;KCNH5;SCN3B;VDAC1;ABCC9;HTT |
potassium channel regulator activity | PRKCZ;KCNIP1;ARPP19A;ABCC9;DPP10;KCNE1L;YWHAE;KCNV1;KCNAB1 |
protein binding | CASP2;SPG21;MPZL2B;PPIB;MED24;KCNE3;LSM4;TRP63;ICAM1 |
protein binding, bridging | TJP2;PPP4R2;TRIM6;CAV2;ANXA1;LOR;SH2D1B;FSCN1;AMFR |
ANK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK2.
Sptan1; Kif3a; SNCA; Ywhae; Ywhaz; Kifap3; Ywhab; Actg1; Dctn4
- Q&As
- Reviews
Q&As (13)
Ask a questionYes, besides its role in cell membrane organization and neuronal function, ANK2 has been implicated in other cellular processes. It is involved in the regulation of cell adhesion, cell migration, and intracellular signaling pathways. ANK2 also interacts with various proteins, including those involved in the immune response, embryonic development, and cancer progression.
Currently, there are no specific drugs designed to target ANK2. However, ongoing research aims to identify compounds that can modulate the function of ANK2 or interact with compromised ANK2 isoforms to alleviate symptoms associated with ANK2 mutations or related disorders.
Yes, animal models, such as mice, have been generated to study ANK2-related disorders and investigate the consequences of ANK2 mutations. These models allow researchers to understand the molecular and physiological impact of ANK2 dysfunction and test potential therapeutic interventions.
Yes, ANK2 mutations have been associated with various cardiac disorders, including long QT syndrome, Brugada syndrome, and arrhythmogenic right ventricular cardiomyopathy (ARVC). These mutations can disrupt the normal function of ANK2 in cell membrane organization and ion channel anchoring, leading to abnormal electrical signaling in the heart.
Diagnosis of ANK2-related disorders typically involves genetic testing, where the ANK2 gene is sequenced to identify any mutations. Additionally, cardiac evaluations including electrocardiograms (ECGs) and other tests can aid in diagnosing cardiac arrhythmias.
Some isoforms of ANK2 exhibit tissue-specific expression patterns. For example, the ANK2 isoform containing exon B is primarily found in the heart, while others may have wide-ranging distribution in different tissues. The specific isoforms expressed in a particular tissue depend on developmental stages and cellular requirements.
Mutations in the ANK2 gene have been linked to certain cardiac arrhythmias, such as Long QT syndrome and atrial fibrillation. These mutations can disrupt the proper localization and function of ion channels involved in regulating the heart's electrical activity.
The ANK2 gene can produce multiple isoforms due to alternative splicing, resulting in proteins of different lengths and functions. Some isoforms of ANK2 are primarily found in the heart, while others are present in various other tissues.
Some studies have suggested a potential link between certain ANK2 mutations and psychiatric disorders, including bipolar disorder and schizophrenia. However, the exact mechanism by which ANK2 mutations predispose individuals to these conditions is not fully understood and requires further investigation.
Yes, ANK2 mutations can be inherited in an autosomal dominant manner, meaning that an affected individual has a 50% chance of passing the mutation onto their offspring. However, spontaneous mutations can also occur, leading to ANK2-related disorders without any family history.
Studies have shown that certain genetic variations or polymorphisms in the ANK2 gene may influence an individual's susceptibility to arrhythmias and cardiac disorders. These variations might affect the expression or function of ANK2, thereby increasing the risk of abnormal cardiac rhythms.
Treatment options for ANK2-related disorders usually focus on managing symptoms and preventing arrhythmias. This can involve medications to regulate heart rhythm, lifestyle modifications, and in some cases, cardiac devices like pacemakers or implantable defibrillators.
Dysfunction of ANK2 in the brain can result in neuronal hyperexcitability and impaired neurotransmission. This can contribute to neurological disorders such as epilepsy, autism spectrum disorders, and intellectual disabilities. Additionally, ANK2 mutations have been linked to increased susceptibility to neurodegenerative diseases like Alzheimer's and Parkinson's.
Customer Reviews (4)
Write a reviewIn addition to the advantages of ANK2 protein itself, the manufacturer can play a crucial role in supporting the research efforts.
This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.
They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.
the manufacturer's technical expertise can be advantageous to researchers.
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