Recombinant Mouse Anks1, His-tagged

• Cat.No.: Anks1-3470M
• Product Overview: Ankyrin repeat and SAM domain-containing protein 1A (Anks1a), partial

Specification

• Source: E. Coli or Yeast
• Species: Mouse
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 1150
• Purity: >90%
• Notes: Small volumes of Anks1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Anks1 ankyrin repeat and SAM domain containing 1 [ Mus musculus ]
• Official Symbol: Anks1
• Synonyms: ankyrin repeat and SAM domain-containing protein 1A; Odin
• Gene ID: 224650
• mRNA Refseq: NM_001286040
• Protein Refseq: NP_001272969
• UniProt ID: P59672
• Chromosome Location: 17 A3.3; 17
• Function: ephrin receptor binding

Reviews

12/22/2019

The reliable performance of the Anks1 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

08/04/2018

The Anks1 protein comes highly recommended for its excellent performance in various research applications.

12/21/2017

Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

06/27/2017

Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

Q&As

What other proteins or pathways does Anks1 interact with?

Anks1 has been reported to interact with several proteins and pathways. One of its well-studied interactions is with the TRPV4 ion channel, which is involved in calcium signaling. Anks1 acts as an adaptor protein, facilitating the interaction between TRPV4 and other signaling molecules, such as calmodulin and protein kinase C.

Has the Anks1 protein been studied in other model organisms besides humans?

Yes, the Anks1 protein has been studied in various model organisms besides humans. Animal models, such as mice, have been used to investigate the function and role of Anks1 in different biological processes. For example, studies have demonstrated that mice lacking Anks1 exhibit skeletal abnormalities, suggesting its involvement in skeletal development and homeostasis.

Is there any association between Anks1 and human diseases?

Currently, there is limited information on the association between Anks1 and human diseases. However, some research suggests that abnormalities in Anks1 expression or function may contribute to certain conditions.

Are there any known protein interactions involving Anks1?

Yes, Anks1 is known to interact with several proteins. One of the well-documented protein interactions involves its binding to the TRPV4 ion channel. Anks1 interacts with TRPV4 through its ankyrin repeat domains and is thought to play a role in the regulation of TRPV4 channel function.

Are there any targeted therapies developed for Anks1-related conditions?

Since the understanding of Anks1's role in specific diseases is still limited, no targeted therapies have been developed for Anks1-related conditions so far. However, continued research into the function and mechanisms of Anks1 could provide valuable insights for potential therapeutic interventions in the future.

Are there any ongoing clinical trials targeting Anks1 or related pathways?

As of now, there are no ongoing clinical trials specifically targeting Anks1 or related pathways. The understanding of Anks1's functions and its potential clinical implications is still in the early stages, which may explain the lack of targeted clinical trials.

Are there any known genetic mutations or variations in the Anks1 gene?

Yes, there have been reports of genetic mutations and variations in the Anks1 gene. For example, a study identified a mutation in the Anks1 gene that is associated with a rare genetic disorder called autosomal recessive nephrogenic diabetes insipidus (NDI). NDI is characterized by the inability of the kidneys to concentrate urine properly, leading to excessive thirst and excessive urine production. This mutation disrupts the function of the Anks1 protein, specifically affecting its interaction with the TRPV4 ion channel, and ultimately leads to the development of NDI.