Recombinant Mouse ARL8A Protein

• Cat.No.: ARL8A-1942M
• Product Overview: Recombinant Mouse ARL8A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Arl8a ADP-ribosylation factor-like 8A [ Mus musculus ]
• Official Symbol: ARL8A
• Gene ID: 68724
• mRNA Refseq: NM_026823.2
• Protein Refseq: NP_081099.1
• UniProt ID: Q8VEH3

Reviews

01/21/2023

Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

08/16/2021

One of the key advantages of working with the ARL8A protein is the comprehensive support provided by its manufacturer.

06/04/2020

Its robust performance has significantly accelerated my research progress and contributed to the advancement of my scientific understanding.

05/29/2019

This information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.

07/23/2017

Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.

06/30/2017

Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

03/26/2017

ARL8A is known for its high purity and quality, ensuring accurate and reproducible results.

08/10/2016

This protein has become an invaluable asset in my research, offering great versatility in its applications.

Q&As

Can ARL8A interact with other cellular organelles besides endosomes and lysosomes?

Yes, studies have shown that ARL8A can interact with other organelles such as the Golgi apparatus and mitochondria. This suggests that ARL8A may have additional functions in cellular processes related to these organelles.

How does ARL8A contribute to lysosome positioning?

ARL8A interacts with the microtubule plus-end-directed kinesin motor proteins to facilitate the transport of lysosomes along microtubules. This interaction helps position lysosomes near the periphery of cells, facilitating efficient fusion with phagosomes or other vesicles.

Are there any therapeutic implications for targeting ARL8A in neurodegenerative diseases?

Dysregulation of lysosome function and trafficking pathways, including those involving ARL8A, has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Targeting ARL8A and related proteins could potentially provide therapeutic strategies to modulate lysosomal dysfunction and alleviate disease pathologies.

Are there any known mutations or genetic disorders associated with ARL8A?

As of now, no genetic disorders or specific mutations in ARL8A have been identified. However, variations or alterations affecting the pathways regulated by ARL8A could potentially contribute to certain diseases or conditions.

What are the known interacting proteins of ARL8A?

ARL8A interacts with various proteins, including SKIP (SifA and kinesin-interacting protein) and VARP (VPS9-ankyrin repeat protein), which are involved in tethering and docking of phagosomes to lysosomes. Other known interacting partners include SKIPR-1, Hook1, and Dynactin.

Can ARL8A be involved in autophagy?

Yes, ARL8A has been shown to play a role in autophagy, a cellular process responsible for the degradation of damaged organelles or proteins. It regulates the maturation and fusion of autophagosomes with lysosomes, aiding in the degradation of the autophagic cargo.

Is ARL8A expressed in all cell types?

ARL8A is expressed in a variety of cell types, including both normal and cancer cells. Its expression levels may vary in different tissues and cell types, suggesting potential cell-specific functions or regulation.

Are there any known natural inhibitors or activators of ARL8A?

Currently, there are no specific natural inhibitors or activators identified for ARL8A. However, studies are ongoing to discover small molecule compounds or modulators that can selectively target ARL8A activity for potential therapeutic applications.

Can ARL8A be involved in immune responses?

Yes, ARL8A has been shown to be involved in immune responses by facilitating phagosome-lysosome fusion and degradation of engulfed pathogens in immune cells. Its interaction with proteins like SKIP and VARP in immune cells helps mediate the intracellular trafficking of phagosomes and regulate immune responses.

Is ARL8A associated with any diseases?

Currently, no specific diseases have been directly linked to ARL8A. However, dysregulation of lysosome-related processes, in which ARL8A is involved, can contribute to conditions such as lysosomal storage disorders and neurodegenerative diseases.

Can ARL8A be targeted for therapeutic intervention?

ARL8A has potential as a therapeutic target due to its involvement in various cellular processes and its role in diseases related to lysosomal dysfunction or membrane trafficking. However, more research is needed to fully understand its mechanisms and develop specific interventions.

Does ARL8A have any interactions with other proteins?

Yes, ARL8A interacts with various proteins to carry out its cellular functions. It interacts with kinesin motor proteins, SKIP, and VARP, among others, to participate in organelle trafficking, immune responses, and phagosome-lysosome fusion.

Is ARL8A found in other organisms besides humans?

Yes, ARL8A proteins are highly conserved across different species, including mammals, flies, worms, and plants. This suggests that ARL8A has important cellular functions that are preserved throughout evolution.