Recombinant Mouse Asap3 Protein, Myc/DDK-tagged

• Cat.No.: Asap3-1733M
• Product Overview: Purified recombinant protein of mouse full-length ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (Asap3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Promotes cell proliferation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 99.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]
• Official Symbol: Asap3
• Synonyms: ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; development and differentiation enhancing factor-like 1; development and differentiation-enhancing factor-like 1; Gm140; UPLC1; Ddefl1; 9430088F20Rik; MGC102639
• Gene ID: 230837
• mRNA Refseq: NM_001008232
• Protein Refseq: NP_001008233
• UniProt ID: Q5U464

Reviews

03/15/2022

The outstanding level of customer service adds extra reassurance and confidence in using the ASAP3 protein for my scientific investigations.

09/29/2019

With the ASAP3 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

10/23/2018

The ASAP3 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

Q&As

Is ASAP3 expressed in immune cells?

ASAP3 has been found in immune cells, indicating its potential involvement in immune responses, though its exact functions in this context remain to be fully elucidated.

Does ASAP3 play a role in cell adhesion?

Yes, ASAP3 is involved in cell adhesion processes by regulating the internalization and recycling of adhesion molecules, such as integrins, at the plasma membrane.

Can ASAP3 be regulated by post-translational modifications?

Yes, ASAP3 can undergo phosphorylation, acetylation, and ubiquitination, which can affect its stability, activity, and protein-protein interactions.

How does ASAP3 regulate membrane trafficking?

ASAP3 stimulates the GTP hydrolysis of Arf6, leading to its inactivation and subsequent modulation of vesicle trafficking pathways, including endocytosis and recycling.

Is ASAP3 involved in cancer progression?

ASAP3 has been suggested to play a role in cancer cell invasion and metastasis due to its influence on cell migration, adhesion, and the actin cytoskeleton.

Are there any genetic variations associated with ASAP3?

Genetic variations in ASAP3 have been identified, and some studies have linked them to certain diseases or phenotypes, although further research is needed to establish definitive associations.

Can ASAP3 interact with other proteins?

Yes, ASAP3 can interact with various proteins involved in membrane trafficking, including clathrin, AP1, AP2, and several adaptor proteins.

Does ASAP3 play a role in neuronal processes?

ASAP3 expression has been observed in neurons, suggesting a potential role in neuronal development, synaptic plasticity, or other neuronal processes, although more investigation is required.