ASAP1
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Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
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Overview
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; DDEF1, development and differentiation enhancing factor 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; centaurin; beta 4; CENTB4; KIAA1249; PAP; ZG14P; DEF-1; cent;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- Rat
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ASAP1-881H | Recombinant Human ASAP1 protein, GST-tagged | Wheat Germ | GST | ||
Human | ASAP1-8668HCL | Recombinant Human ASAP1 293 Cell Lysate | HEK293 | N/A | ||
Human | ASAP1-1259HF | Recombinant Full Length Human ASAP1 Protein, GST-tagged | In Vitro Cell Free System | GST | 36 amino acids | |
Mouse | ASAP1-2002M | Recombinant Mouse ASAP1 Protein | Mammalian Cell | His | ||
Mouse | ASAP1-772M | Recombinant Mouse ASAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ASAP1-772M-B | Recombinant Mouse ASAP1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ASAP1-816R | Recombinant Rat ASAP1 Protein | Mammalian Cell | His | ||
Rat | ASAP1-472R | Recombinant Rat ASAP1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ASAP1-472R-B | Recombinant Rat ASAP1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bovine | ASAP1-3617B | Recombinant Bovine ASAP1, His-tagged | E.Coli or Yeast | His | 1129 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ASAP1 Related Articles
ASAP1 involved in several pathways and played different roles in them. We selected most pathways ASAP1 participated on our site, such as Endocytosis, Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | USP8;MVB12B;EHD2;RAB31;CBL;RAB8A;SH3GL1;CXCR4;SH3GL1B |
Fc gamma R-mediated phagocytosis | LIMK1;GAB2;MARCKSL1;NCF1;ARPC5L;LAT;CDC42;PPAP2A;HCK |
ASAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP1 itself. We selected most functions ASAP1 had, and list some proteins which have the same functions with ASAP1. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | PLCB1;ARHGAP17;ARHGAP20;PREX2;ARHGEF6;GIT1;RGS20;ARHGAP33;DEPDC1B |
metal ion binding | ZNF37A;TGM2B;NRP2A;ADARB1;HSPB11;TRIM35-21;ZNF493;GMEB1;CH25HL2 |
phosphatidylinositol-3,4,5-trisphosphate binding | ADAP2;MAPKAP1;DAPP1;ARAP3;D6WSU116E;BTK;ASAP1;PIRT;INPPL1 |
phosphatidylinositol-4,5-bisphosphate binding | ALOX15;JPH2;MARK1;MYO1G;SNX18;EXOC1;MAPKAP1;SLC9A1;RPH3A |
protein binding | LRRC4;KRT80;SLC6A18;CHCHD1;PKN3;STOML2;TGS1;ASPSCR1;GAS2L3 |
ASAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP1.
GRB2; CTTN; SH3KBP1
- Q&As
- Reviews
Q&As (7)
Ask a questionASAP1 binds to actin-binding proteins and actin regulatory proteins, enabling it to regulate actin dynamics and cytoskeleton rearrangements in response to cellular signaling.
ASAP1's Arf-GAP activity influences processes such as endocytosis, exocytosis, membrane recycling, and protein trafficking.
Yes, ASAP1 expression levels can be dysregulated in certain cancer types, leading to increased invasiveness and poor prognosis.
Yes, ASAP1 has been implicated in cancer progression, promoting cell migration, invasion, and metastasis.
ASAP1 is found predominantly at the plasma membrane, where it participates in various cellular activities.
ASAP1 interacts with various proteins, including members of the Arf family, components of the endocytic machinery, regulators of actin dynamics, and other signal transduction molecules.
Mutations or genetic variations in ASAP1 have not been extensively reported, but further research is required to explore their potential associations.
Customer Reviews (3)
Write a reviewI have found the ASAP1 Protein to be highly stable, enabling long-term experiments without compromising its performance.
One aspect that sets the ASAP1 Protein apart is the excellent technical support provided by the manufacturer.
The ASAP1 Protein is an exceptional product that fully meets my experimental needs.
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