Recombinant Mouse Ascc1 Protein, Myc/DDK-tagged

• Cat.No.: Ascc1-1737M
• Product Overview: Purified recombinant protein of mouse full-length activating signal cointegrator 1 complex subunit 1 (Ascc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 41.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ascc1 activating signal cointegrator 1 complex subunit 1 [ Mus musculus (house mouse) ]
• Official Symbol: Ascc1
• Synonyms: ASCC1; activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit p50; trip4 complex subunit p50; CGI-18; ASC1p50; AI550520; 1810015P09Rik
• Gene ID: 69090
• mRNA Refseq: NM_026937
• Protein Refseq: NP_081213
• UniProt ID: Q9D8Z1

Reviews

11/25/2022

the use of ASCC1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

05/24/2018

The manufacturer's support and expertise further enhance the utility of ASCC1 in my experimental work, ensuring reliable and high-quality results.

11/13/2017

This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.

Q&As

How is ASCC1 localization regulated within the cell?

ASCC1 is primarily localized in the nucleus of cells, where it functions in gene expression regulation. It is believed to shuttle between the nucleus and cytoplasm upon specific cellular signaling events.

Does ASCC1 have any post-translational modifications?

The post-translational modifications of ASCC1 have not been extensively studied. However, it is possible that ASCC1 undergoes modifications such as phosphorylation or acetylation, which can regulate its function.

Does ASCC1 have any role in DNA repair processes?

Yes, ASCC1 is involved in DNA repair processes as part of the ASC-1 complex. It participates in the repair of DNA double-strand breaks, contributing to genome stability.

In which tissues or cell types is ASCC1 expressed?

ASCC1 is expressed in a wide range of tissues and cell types, including but not limited to the brain, liver, heart, and skeletal muscle.

Is there any association between ASCC1 and human diseases?

Currently, there are no known human diseases directly associated with ASCC1. However, dysregulation of transcriptional coactivation complexes, in which ASCC1 is involved, can contribute to various diseases.

Can ASCC1 be targeted for therapeutic interventions or drug discovery?

Given the limited understanding of ASCC1's specific role in diseases, it is currently uncertain if it can be directly targeted for therapeutic interventions or drug discovery.

What are the known interacting partners of ASCC1?

ASCC1 interacts with various proteins and transcription factors, such as ATF2, TAF12, and TRIM28, to form the ASC-1 complex and regulate gene expression.