Recombinant Mouse Ascc2 Protein, Myc/DDK-tagged
Cat.No. : | Ascc2-1738M |
Product Overview : | Purified recombinant protein of mouse full-length activating signal cointegrator 1 complex subunit 2 (Ascc2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 85.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ascc2 activating signal cointegrator 1 complex subunit 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Ascc2 |
Synonyms : | ASCC2; activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; trip4 complex subunit p100; AI482016; ASC1p100; AW046480; RP23-280J3.3; 1700011I11Rik; 2610034L15Rik; FLJ21588 |
Gene ID : | 75452 |
mRNA Refseq : | NM_029291 |
Protein Refseq : | NP_083567 |
UniProt ID : | Q91WR3 |
Products Types
◆ Recombinant Protein | ||
ASCC2-900H | Recombinant Human ASCC2 protein, GST-tagged | +Inquiry |
ASCC2-10748Z | Recombinant Zebrafish ASCC2 | +Inquiry |
◆ Lysates | ||
ASCC2-8655HCL | Recombinant Human ASCC2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCurrently, there are no known human diseases directly associated with ASCC2. However, dysregulation of transcriptional coactivation complexes, in which ASCC2 is involved, can contribute to various diseases.
The direct impact of ASCC2 on cellular metabolism is not well-documented. However, given its role in transcriptional regulation, it may indirectly influence metabolic processes by controlling gene expression.
The post-translational modifications of ASCC2 have not been extensively studied. However, it is possible that ASCC2 may undergo modifications such as phosphorylation or acetylation, which can regulate its activity.
ASCC2 is primarily localized in the nucleus, where it carries out its functions in gene expression regulation.
ASCC2 is known to be involved in DNA repair processes as part of the ASC-1 complex. It contributes to the repair of DNA double-strand breaks, promoting genome stability.
Customer Reviews (3)
Write a reviewAnother advantage of using ASCC2 protein in trials is its potential as a therapeutic agent.
Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ANXA5B.
The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.
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