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Recombinant Mouse Ascc2 Protein, Myc/DDK-tagged

Cat.No. : Ascc2-1738M
Product Overview : Purified recombinant protein of mouse full-length activating signal cointegrator 1 complex subunit 2 (Ascc2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 85.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ascc2 activating signal cointegrator 1 complex subunit 2 [ Mus musculus (house mouse) ]
Official Symbol : Ascc2
Synonyms : ASCC2; activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; trip4 complex subunit p100; AI482016; ASC1p100; AW046480; RP23-280J3.3; 1700011I11Rik; 2610034L15Rik; FLJ21588
Gene ID : 75452
mRNA Refseq : NM_029291
Protein Refseq : NP_083567
UniProt ID : Q91WR3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is there any association between ASCC2 and human diseases? 03/26/2023

Currently, there are no known human diseases directly associated with ASCC2. However, dysregulation of transcriptional coactivation complexes, in which ASCC2 is involved, can contribute to various diseases.

Does ASCC2 have any impact on cellular metabolism? 04/25/2021

The direct impact of ASCC2 on cellular metabolism is not well-documented. However, given its role in transcriptional regulation, it may indirectly influence metabolic processes by controlling gene expression.

Does ASCC2 undergo any post-translational modifications? 03/09/2018

The post-translational modifications of ASCC2 have not been extensively studied. However, it is possible that ASCC2 may undergo modifications such as phosphorylation or acetylation, which can regulate its activity.

How is ASCC2 localized within the cell? 02/05/2018

ASCC2 is primarily localized in the nucleus, where it carries out its functions in gene expression regulation.

Is ASCC2 involved in DNA repair processes? 08/22/2017

ASCC2 is known to be involved in DNA repair processes as part of the ASC-1 complex. It contributes to the repair of DNA double-strand breaks, promoting genome stability.

Customer Reviews (3)

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Reviews
03/07/2020

    Another advantage of using ASCC2 protein in trials is its potential as a therapeutic agent.

    05/13/2017

      Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ANXA5B.

      02/18/2017

        The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

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