Recombinant Mouse ATP2B3 Protein, His-tagged

• Cat.No.: ATP2B3-12M
• Product Overview: Recombinant Mouse ATP2B3 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Predicted to be involved in calcium ion export across plasma membrane and regulation of cytosolic calcium ion concentration. Predicted to be located in membrane raft; parallel fiber; and plasma membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: 50mM Tris 300mM NaCl, pH 8.0.
• Molecular Mass: 24.5 kDa
• AA Sequence: MGSSHHHHHHSSGLVPRGSHMQFGG KPFSCSPLSTEQWLWCLFVGVGELV WGQVIATIPTSQLKCLKEAGHGPGK DEMTDEELAEGEEEIDHAERELRRG QILWFRGLNRIQTQIRVVKAFRSSL YEGLEKPESKSCIHNFMATPEFLIN DYTHNIPLIDDTDVDENEERLRAPP PPPPNQNNNAIDSGIYLTTHATKSA TSSAFSSRPGSPLHSMETSL
• Purity: ＞90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.27 mg/ml

Gene Information

• Gene Name: Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 [ Mus musculus (house mouse) ]
• Official Symbol: ATP2B3
• Synonyms: Pmca3; 6430519O13Rik
• Gene ID: 320707
• mRNA Refseq: NM_177236
• Protein Refseq: NP_796210
• MIM: 300014
• UniProt ID: Q0VF55

Reviews

06/28/2022

ATP2B3 were of very high quality and reliable, which is very helpful to our results.

04/08/2022

Due to the high purity of ATP2B3, its production process is very quality-oriented.

12/03/2019

The reproducibility of ATP2B3 is very good, and the results of each experiment are very consistent, indicating that its production process is very careful.

Q&As

How is the protein structure and function of ATP2B3 different from other atpase B family members?

There are several differences in protein structure and function between ATP2B3 and other atpase B family members, mainly depending on how they are expressed and regulated in different tissues and cells.

Are mutations in ATP2B3 associated with rare genetic diseases?

ATP2B3 gene mutation may be associated with some hereditary diseases such as pigmentary papillomatosis and atrial fibrillation/flutte

Is ATP2B3 associated with neurological diseases?

At present, studies have shown that ATP2B3 is associated with nervous system diseases such as Parkinson's disease and Alzheimer's disease.

What are the pathways of ATP2B3 protein production?

The production pathway of ATP2B3 protein mainly includes multiple biological processes such as gene transcription, RNA splicing, protein translation and subsequent modification.

What is the regulatory mechanism of ATP2B3?

The regulatory mechanism of ATP2B3 may involve multiple signaling pathways and factors, such as calcium ions, ATP, membrane receptors, etc.

What is the relationship between ATP2B3 and cardiovascular disease?

The relationship between ATP2B3 and cardiovascular disease may be achieved through several mechanisms such as regulating cardiomyocyte contraction and vascular smooth muscle cell contraction.