Recombinant Mouse Capn2 Protein, GST-tagged

• Cat.No.: Capn2-362M
• Product Overview: Recombinant Mouse Capn2 Protein (Glu33-Thr344) with N-GST tag was expressed in E. coli.

Specification

• Description: Enables calcium-dependent cysteine-type endopeptidase activity. Involved in cellular response to amino acid stimulus and proteolysis. Acts upstream of or within blastocyst development and myoblast fusion. Located in several cellular components, including chromatin; cytosol; and lysosome. Is expressed in several structures, including hindbrain; lens epithelium; oral region epithelium; skin; and spinal cord floor plate. Orthologous to human CAPN2 (calpain 2).
• Source: E. coli
• Species: Mouse
• Tag: N-GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 64.9 kDa
  Accurate Molecular Mass: 65 kDa
• Protein length: Glu33-Thr344
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Capn2 calpain 2 [ Mus musculus (house mouse) ]
• Official Symbol: Capn2
• Synonyms: CAPN2; calpain 2; calpain-2 catalytic subunit; CALP80; CANP 2; calpain M-type; millimolar-calpain; cysteine proteinase; calpain-2 large subunit; m-calpain large subunit; 80 kDa M-calpain subunit; m-calpain 80 kDa large subunit; calcium-activated neutral proteinase 2; Capa2; Capa-2; AI326419; m-calpin; m-calpain
• Gene ID: 12334
• mRNA Refseq: NM_009794
• Protein Refseq: NP_033924
• UniProt ID: O08529

Reviews

03/05/2020

The CAPN2 protein has been extensively studied and validated in various experimental applications.

08/03/2019

Their team of technical experts possess deep knowledge and expertise regarding the protein, ensuring that researchers receive accurate and timely assistance.

10/01/2017

In addition to its advantages in trials, the manufacturer of the CAPN2 protein offers exceptional support to researchers.

Q&As

How is CAPN2 protein expression regulated in normal physiological conditions?

CAPN2 activity is tightly regulated by intracellular calcium levels and various other factors to maintain cellular homeostasis.

How does CAPN2 protein interact with other molecules or proteins in disease contexts?

CAPN2 interacts with various cellular proteins, contributing to processes like protein degradation, cytoskeletal remodeling, and cell signaling, influencing disease pathways.

Can CAPN2 protein serve as a potential therapeutic target?

Research suggests that modulating CAPN2 activity could be a potential therapeutic strategy for managing diseases associated with its dysregulation.

Are there any drugs or compounds known to modulate CAPN2 activity?

Some compounds and inhibitors targeting CAPN2 have been developed in preclinical studies, showing promise in controlling its activity for therapeutic purposes.

Can CAPN2 protein levels serve as a biomarker for certain diseases?

In some cases, altered levels of CAPN2 have been observed in disease states, suggesting its potential as a biomarker, but further validation is needed.