Recombinant Mouse Ddx41 Protein, Myc/DDK-tagged

• Cat.No.: Ddx41-2508M
• Product Overview: Purified recombinant protein of mouse full-length DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (Ddx41), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ubiquitous expression in ovary adult (RPKM 33.6), spleen adult (RPKM 30.7) and 28 other tissues.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 69.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ddx41 DEAD box helicase 41 [ Mus musculus (house mouse) ]
• Official Symbol: Ddx41
• Synonyms: DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD-box protein abstrakt; ABS; AA958953; AI324246; 2900024F02Rik
• Gene ID: 72935
• mRNA Refseq: NM_134059
• Protein Refseq: NP_598820
• UniProt ID: Q3UAC4

Reviews

04/16/2020

Compatibility with standard laboratory instruments made the product user-friendly in our well-equipped facility.

11/11/2019

Our suggestions for enhancements were acknowledged, fostering a collaborative relationship with the product's provider.

01/12/2019

Clear and comprehensive training materials provided a solid foundation for understanding the product's application.

Q&As

In which cellular compartments is DDX41 predominantly localized?

DDX41 is predominantly localized in the cytoplasm of cells, where it carries out its functions in nucleic acid recognition and immune sensing.

What is the primary function of DExD/H-box helicase 41 (DDX41) in cellular processes and nucleic acid metabolism?

DExD/H-box helicase 41 (DDX41) functions in cellular processes, primarily playing a role in nucleic acid metabolism and immune responses.

How does DDX41 recognize and interact with nucleic acids, including RNA and DNA?

DDX41 recognizes and interacts with nucleic acids, including RNA and DNA, through its DExD/H-box helicase domain.

What is the role of DDX41 in innate immune responses, particularly in sensing viral or microbial infections?

The role of DDX41 in innate immune responses involves sensing viral or microbial infections and triggering antiviral signaling pathways.

What diseases or conditions are associated with dysregulation or abnormal expression of DDX41?

Dysregulation or abnormal expression of DDX41 is associated with conditions such as myelodysplastic syndromes and certain cancers.

How does DDX41 contribute to the activation of antiviral signaling pathways, such as the interferon response?

DDX41 contributes to the activation of antiviral signaling pathways, including the induction of interferon responses against viral infections.

Are there therapeutic implications or potential targets related to DDX41 in diseases involving immune responses?

There are potential therapeutic implications related to DDX41 in diseases involving immune responses, making it a target for drug development.