DDX41
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
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Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. -
Synonyms
DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41; AI324246; zgc:55896; 2900024F02Rik; AA958953; ABS; DEAD box protein 41; DEAD box protein abstrakt homolog; EC 3.6.1.-; fb92e02; MGC55896; MGC8828; wu:fb92e02; OTTHUMP00000161451; OTTHUMP00000223824; putative RNA helicase; DEAD-box protein abstrakt;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
DDX41 involved in several pathways and played different roles in them. We selected most pathways DDX41 participated on our site, such as Cytosolic sensors of pathogen-associated DNA, IRF3-mediated induction of type I IFN, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX41 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytosolic sensors of pathogen-associated DNA | POLR3G;TICAM1;POLR3H;NLRP4B;DDX41;POLR3GLA;IFI16;ALCAMB;S100A12 |
| IRF3-mediated induction of type I IFN | NLRP4;TREX1;IFI16;NLRP4C;NLRP4E;DDX41;NLRP4B |
| Immune System | TREX1;ASB9;SIRPB1;CD300E;ICAM4;EIF4G2A;KLRB1A;AP1S1;NOD1 |
| Innate Immune System | Txn1;BTR30;DEFB4A;BTR02;GZMM;MGC174857;BTR29;DEFB4B;PANX1A |
| Regulation of innate immune responses to cytosolic DNA | NLRP4;DDX41;NLRP4B;NLRP4C;TRIM56;NLRP4E;TREX1 |
| STING mediated induction of host immune responses | MB21D1;NLRP4;NLRP4B;TREX1;NLRP4C;NLRP4E;DDX41;IFI16 |
DDX41 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX41 itself. We selected most functions DDX41 had, and list some proteins which have the same functions with DDX41. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2B3B;ATP7A;LARS;KIF11;CHEK2;PAK1;GATC;CDC42BPA;DHX36 |
| ATP-dependent RNA helicase activity | DDX23;UPF1;DDX56;EIF4A1;DDX6;DDX5;DHX8;DHX9;CHST13 |
| DNA binding | HOXD10A;ZNF468;TAF13;KCNIP3;NOTO;SSH2;EMX3;CDT1;ZNF350 |
| poly(A) RNA binding | MRPL9;DQX1;EIF5B;EXOSC10;TPT1;FCF1;NCBP1;ENO1;EMG1 |
| protein binding | PTPRA;RRAGB;TNIP3;FOXP1;TUBA1C;SKA3;CST7;RHOB;TFPT |
| zinc ion binding | VDRA;TET1;TRIM3;AMFR;ADAM30;ZNF75D;GATAD1;NR1H2;CRIP1 |
DDX41 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX41 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX41.
SIAH1; CEP70; NKAP; ABL1; FYN; CRK; RNPS1; Ddx41; USP36; gltX; E2F3; DVL2; ANXA1; SNW1; Vps41
- Q&As
- Reviews
Q&As (7)
Ask a questionDDX41 is predominantly localized in the cytoplasm of cells, where it carries out its functions in nucleic acid recognition and immune sensing.
DExD/H-box helicase 41 (DDX41) functions in cellular processes, primarily playing a role in nucleic acid metabolism and immune responses.
DDX41 recognizes and interacts with nucleic acids, including RNA and DNA, through its DExD/H-box helicase domain.
The role of DDX41 in innate immune responses involves sensing viral or microbial infections and triggering antiviral signaling pathways.
Dysregulation or abnormal expression of DDX41 is associated with conditions such as myelodysplastic syndromes and certain cancers.
DDX41 contributes to the activation of antiviral signaling pathways, including the induction of interferon responses against viral infections.
There are potential therapeutic implications related to DDX41 in diseases involving immune responses, making it a target for drug development.
Customer Reviews (3)
Write a reviewCompatibility with standard laboratory instruments made the product user-friendly in our well-equipped facility.
Our suggestions for enhancements were acknowledged, fostering a collaborative relationship with the product's provider.
Clear and comprehensive training materials provided a solid foundation for understanding the product's application.
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