Recombinant Mouse Dhodh Full Length Transmembrane protein, His-tagged

• Cat.No.: Dhodh-2368M
• Product Overview: Recombinant Mouse Dhodh protein(O35435)(11-395aa), fused to C-terminal His tag, was expressed in E. coli.

Specification

• Source: In vitro E. coli expression system
• Species: Mouse
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 44.2 kDa
• Protein Length: 11-395aa
• AA Sequence: LDAAIILGGGGLLFTSYLTATGDDH FYAEYLMPALQRLLDPESAHRLAVR VISLGLLPRATFQDSNMLEVRVLGH KFRNPVGIAAGFDKHGEAVDGLYKL GFGFVEVGSVTPQPQEGNPRPRVFR LPEDQAVINRYGFNSHGLSAVEHRL RARQQKQTQLTTDGLPLGINLGKNK TSVDAAADYVEGVRILGPLADYLVV NVSSPNTAGLRSLQGKTELRRLLSK VLQERDALKGPQKPAVLVKIAPDLT AQDKEDIASVARELGIDGLIITNTT VSRPVGLQGALRSETGGLSGKPLRD LSTQTIREMYALTQGTIPIIGVGGV SSGQDALEKIQAGASLVQLYTALTF LGPPVVARVKRELEALLKERGFNTV TDAIGVDHRR
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: Dhodh dihydroorotate dehydrogenase [ Mus musculus ]
• Official Symbol: Dhodh
• Synonyms: DHODH; dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; DHOdehase; dihydroorotate oxidase; dihydroorotate dehydrogenase, mitochondrial; AI834883; 2810417D19Rik
• Gene ID: 56749
• mRNA Refseq: NM_020046
• Protein Refseq: NP_064430

Reviews

07/29/2020

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11/03/2017

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05/05/2017

Reliable data, essential for our protein research.

Q&As

How does DHODH contribute to pyrimidine biosynthesis?

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism?

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway?

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth?

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis?

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases?

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment?

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.