Recombinant Mouse Foxa1 Protein, MYC/DDK-tagged

• Cat.No.: Foxa1-1146M
• Product Overview: Purified recombinant protein of full-length mouse forkhead box A1 (Foxa1), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: Biased expression in stomach adult (RPKM 30.0), colon adult (RPKM 27.6) and 9 other tissues
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 49.3 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Foxa1 forkhead box A1 [ Mus musculus (house mouse) ]
• Official Symbol: Foxa1
• Synonyms: Foxa1; forkhead box A1; Hnf3a; Tcf3a; Hnf-3a; Tcf-3a; hepatocyte nuclear factor 3-alpha; HNF-3-alpha; fork head domain; forkhead box protein A1; hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
• Gene ID: 15375
• mRNA Refseq: NM_008259
• Protein Refseq: NP_032285
• UniProt ID: P35582

Reviews

02/03/2023

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

12/15/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

06/11/2017

In addition to its scientific merits, the manufacturer of FOXA1 protein stands out for its outstanding technical support.

Q&As

How does FOXA1 protein contribute to the development of liver cancer?

FOXA1 has been implicated in the development and progression of hepatocellular carcinoma, with its expression levels serving as a potential prognostic marker.

Is FOXA1 protein involved in the regulation of estrogen receptor signaling?

Yes, FOXA1 is a key co-regulator of estrogen receptor (ER) signaling, influencing the expression of ER-responsive genes and impacting the response to anti-estrogen therapies.

Can FOXA1 protein expression be used as a predictive biomarker in lung cancer?

FOXA1 expression has been associated with specific subtypes of lung cancer and may hold potential as a predictive biomarker for treatment response.

Are there any clinical trials investigating the role of FOXA1 protein in cancer treatment?

Yes, there are clinical trials focused on understanding the role of FOXA1 in cancer and exploring its potential as a therapeutic target in various cancer types.

How does FOXA1 protein influence the response to anti-androgen therapy in prostate cancer?

High FOXA1 expression has been linked to resistance to anti-androgen therapy in prostate cancer, highlighting its clinical relevance in treatment decision-making.