Recombinant Mouse Il36a protein, His-tagged

• Cat.No.: Il1f6-49M
• Product Overview: Recombinant mouse Il36a, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: Il36a also known as Interleukin-36 alpha. Il36a participates in cytokine/chemokine production in the epithelium. Part of the Il36a signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Liquid. In Phosphate Buffered Saline (pH7.4) containing 10% glycerol
• Molecular Mass: 20.4kDa (183aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNKEKEL RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYMGVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMIVVH
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: Il1f6 interleukin 1 family, member 6 [ Mus musculus ]
• Official Symbol: Il1f6
• Synonyms: Fil1; Il1f9; Il36a; IL-1H1; IL1RP2; FIL1 epsilon; Fil1epsilon; IL-1 epsilon; IL-1F6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin-1 epsilon; interleukin-1 family member 6; interleukin-1 homolog 1
• Gene ID: 54448
• mRNA Refseq: NM_019450
• Protein Refseq: NP_062323
• UniProt ID: Q9JLA2
• Chromosome Location: 2 A3; 2 16.26 cM
• Function: cytokine activity; interleukin-1 receptor binding; interleukin-1 receptor binding

Reviews

07/20/2022

When conducting experiments with HSP90AA1, clear and reliable interpretation of results can be obtained.

03/12/2021

The IL36A product has low endotoxin levels and does not interfere with experimental results.

08/12/2020

IL36A has important application value in the field of drug research and development, and has achieved certain research results.

Q&As

Does IL36A carry a fever risk?

In general, the use of IL36A does not cause significant fever reactions, but individual differences exist, if there are abnormalities, please consult a doctor.

How to prepare IL36A?

The IL36A is expressed, purified, and constructed using recombinant DNA technology in a suitable host expression system, usually through genetic engineering.

In what inflammatory diseases does recombinant IL36A have potential applications?

IL36A has potential application value in psoriasis, arthritis and other inflammatory diseases, but the specific efficacy needs further study.

Does IL36A have anti-tumor effects?

IL36A has been shown in some studies to have anti-proliferative and anti-invasive effects on certain tumors, but more studies are needed to confirm its specific mechanism of action and effect.

How is the research progress of IL36A?

The research of IL36A is progressing continuously, and some studies have shown its potential in immune regulation, anti-inflammatory effect and so on.

Can IL36A be used in animal experiments?

Yes, IL36A can be used in animal studies to investigate its mechanism of action and potential applications.