| Description : |
Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
68.5 kDa |
| Protein Length : |
917 |
| AA Sequence : |
MSAPRIWLAQALLFFLTTESIGQLL EPCGYIYPEFPVVQRGSNFTAICVL KEACLQHYYVNASYIVWKTNHAAVP REQVTVINRTTSSVTFTDVVLPSVQ LTCNILSFGQIEQNVYGVTMLSGFP PDKPTNLTCIVNEGKNMLCQWDPGR ETYLETNYTLKSEWATEKFPDCQSK HGTSCMVSYMPTYYVNIEVWVEAEN ALGKVSSESINFDPVDKVKPTPPYN LSVTNSEELSSILKLSWVSSGLGGL LDLKSDIQYRTKDASTWIQVPLEDT MSPRTSFTVQDLKPFTEYVFRIRSI KDSGKGYWSDWSEEASGTTYEDRPS RPPSFWYKTNPSHGQEYRSVRLIWK ALPLSEANGKILDYEVILTQSKSVS QTYTVTGTELTVNLTNDRYVASLAA RNKVGKSAAAVLTIPSPHVTAAYSV VNLKAFPKDNLLWVEWTPPPKPVSK YILEWCVLSENAPCVEDWQQEDATV NRTHLRGRLLESKCYQITVTPVFAT GPGGSESLKAYLKQAAPARGPTVRT KKVGKNEAVLAWDQIPVDDQNGFIR NYSISYRTSVGKEMVVHVDSSHTEY TLSSLSSDTLYMVRMAAYTDEGGKD GPEFTFTTPKFAQGEIEAIVVPVCL AFLLTTLLGVLFCFNKRDLIKKHIW PNVPDPSKSHIAQWSPHTPPRHNFN SKDQMYSDGNFTDVSVVEIEANNKK PCPDDLKSVDLFKKEKVSTEGHSSG IGGSSCMSSSRPSISSNEENESAQS TASTVQYSTVVHSGYRHQVPSVQVF SRSESTQPLLDSEERPEDLQLVDSV DGGDEILPRQPYFKQNCSQPEACPE ISHFERSNQVLSGNEEDFVRLKQQQ VSDHISQPYGSEQRRLFQEGSTADA LGTGADGQMERFESVGMETTIDEEI PKSYLPQTVRQGGYMPQ |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
