Recombinant Mouse Interleukin 1 Receptor-like 1, Fc-tagged

• Cat.No.: Il1rl1-1752M
• Product Overview: Recombinant Mouse Il1rl1 encoding the extracellular domain (amino acid residues Met 1 - Ser 342) was fused to the Fc region of human IgG1 via a polypeptide linker, inserted into a suitable baculovirus expression vector and expressed inSf21 cells.

Specification

• Cat. No.: Il1rl1-1752M
• Description: ST2 belongs to the immunoglobulin superfamily and bears significant amino acid identity (~25%) to the extracellular portion of both type I and type II interleukin 1 receptors (IL-1R). Some of the intracellular residues that are required for signal transduction through the IL-1R and are conserved in the Drosophila Toll protein are also found in the membrane form of ST2. Furthermore, the gene for ST2 was mapped to mouse chromosome 1 closely linked to the il-1r locus containing both type I and type II receptor genes in support of their common ancestry.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-1 R4 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 73 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 EU/µg as determined by the LAL method.
• Biological Activity: The biological activity of Mouse IL-1 R4 was determined by its ability to bind rmIL-33 in a functional ELISA type binding assay. The estimated KD is < 50 nM.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus ]
• Synonyms: Il1rl1; interleukin 1 receptor-like 1; T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1; T1; lymphocyte antigen 84; ST2; T1 gene
• Gene ID: 17082
• mRNA Refseq: NM_001025602
• Protein Refseq: NP_001020773
• UniProt ID: P14719
• Chromosome Location: 1 B; 1 20.0 cM
• Function: interleukin-1 receptor activity; interleukin-33 binding; interleukin-33 receptor activity; protein binding; receptor activity; transmembrane receptor activity

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.