Recombinant Mouse Interleukin 11 Receptor, Alpha Chain 1
Cat.No. : | Il11ra1-1759M |
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Cat. No. : | Il11ra1-1759M |
Description : | Interleukin 11 receptor alpha (IL11RA) is a subunit of the interleukin 11 receptor that is expressed in hematopoietic and other organs. IL11RA is a functional target in bone metastasis and is considered as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse IL-11 Rα is Mr 65 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Il11ra1 interleukin 11 receptor, alpha chain 1 [ Mus musculus ] |
Synonyms : | Il11ra1; interleukin 11 receptor, alpha chain 1; NR1; GP130; Il11ra; Il-11ra; Il11ra2; AI314697; locus 2; Il-11ra-alpha; OTTMUSP00000007071; OTTMUSP00000007072; OTTMUSP00000007073; OTTMUSP00000007074; interleukin 11 receptor, alpha chain 2 |
Gene ID : | 16157 |
mRNA Refseq : | NM_001163401 |
Protein Refseq : | NP_001156873 |
UniProt ID : | Q64385 |
Chromosome Location : | 4 A5; 4 12.7 cM |
Pathway : | Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | cytokine receptor activity; interleukin-11 binding; interleukin-11 receptor activity; receptor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAdvanced imaging techniques visualize IL11RA1 conformational changes upon ligand binding.
Animal models and transgenics study IL11RA1's tissue-specific functions.
Reporter gene assays study IL11RA1 gene expression regulation.
High-throughput screening identifies small molecules modulating IL11RA1 activity.
Functional genomics unveil IL11RA1's role in disease pathogenesis.
Site-directed mutagenesis reveals the binding interface of IL11RA1 and IL11.
Fluorescence resonance energy transfer (FRET) reveals IL11RA1 signaling pathways.
Circular dichroism (CD) spectroscopy probes IL11RA1 secondary structure changes.
Proteomics identifies IL11RA1-interacting proteins and signaling complexes.
Surface plasmon resonance (SPR) quantifies IL11RA1 binding kinetics.
Customer Reviews (3)
Write a reviewGood for cytokine assays.
Effective in signaling studies.
Consistent bioactivity.
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