Recombinant Mouse Picalm Protein, Myc/DDK-tagged
Cat.No. : | Picalm-4852M |
Product Overview : | Purified recombinant protein of mouse full-length phosphatidylinositol binding clathrin assembly protein (cDNA clone MGC:19382 IMAGE:2651109), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 123.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Picalm phosphatidylinositol binding clathrin assembly protein [ Mus musculus (house mouse) ] |
Official Symbol : | Picalm |
Synonyms : | Picalm; phosphatidylinositol binding clathrin assembly protein; fit; CALM; CLTH; fit-; fit1; fit-1; PAP180; mKIAA4114; phosphatidylinositol-binding clathrin assembly protein; clathrin assembly lymphoid myeloid leukemia |
Gene ID : | 233489 |
mRNA Refseq : | NM_146194 |
Protein Refseq : | NP_666306 |
UniProt ID : | Q7M6Y3 |
Products Types
◆ Recombinant Protein | ||
PICALM-2589H | Recombinant Human PICALM Protein, His-tagged | +Inquiry |
PICALM-1676H | Recombinant Human PICALM Protein, His (Fc)-Avi-tagged | +Inquiry |
PICALM-4104R | Recombinant Rat PICALM Protein, His (Fc)-Avi-tagged | +Inquiry |
PICALM-3240R | Recombinant Rhesus Macaque PICALM Protein, His (Fc)-Avi-tagged | +Inquiry |
PICALM-3422R | Recombinant Rhesus monkey PICALM Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PICALM-3199HCL | Recombinant Human PICALM 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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