Recombinant Mouse Robo1 Protein, Myc/DDK-tagged

• Cat.No.: Robo1-5566M
• Product Overview: Purified recombinant protein of mouse full-length roundabout guidance receptor 1 (Robo1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 176.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Robo1 roundabout guidance receptor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Robo1
• Synonyms: ROBO1; roundabout homolog 1 (Drosophila); roundabout homolog 1; DUTT1; Gm310; AW494633; AW742721
• Gene ID: 19876
• mRNA Refseq: NM_019413
• Protein Refseq: NP_062286
• UniProt ID: O89026

Reviews

06/28/2023

ROBO1 is able to maintain its biological activity and structural integrity under specific experimental conditions.

06/07/2022

ROBO1 products have low endotoxin levels and do not interfere with experimental results.

07/31/2021

When using ROBO1 for experiments, you can get a clear and reliable interpretation of your results.

Q&As

What is the association between ROBO1 recombinant protein and tumors?

Some studies have shown that ROBO1 recombinant protein may be involved in the initiation and progression of tumors, especially in neurological tumors.

Does ROBO1 recombinant protein function in pregnant women?

The level of ROBO1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

Does ROBO1 have a function in the human body?

ROBO1 is mainly involved in axon guidance and neural network formation in the human body, affecting the development and function of the nervous system.

If the level of ROBO1 recombinant protein is abnormal, what should I do?

If the level of ROBO1 recombinant protein is abnormal, treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

Is there a treatment for ROBO1 recombinant proteins?

The current treatments for ROBO1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for axon guidance.

What is the association between ROBO1 recombinant protein and neurological diseases?

ROBO1 recombinant protein may be involved in the occurrence and progression of neurological diseases, especially in glioma, neural tube defects, and autism.