Recombinant Mouse Rxrg Protein, Myc/DDK-tagged

• Cat.No.: Rxrg-5660M
• Product Overview: Purified recombinant protein of mouse full-length retinoid X receptor gamma (Rxrg), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 50.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rxrg retinoid X receptor gamma [ Mus musculus (house mouse) ]
• Official Symbol: Rxrg
• Synonyms: RXRG; retinoid X receptor gamma; retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3; Nr2b3
• Gene ID: 20183
• mRNA Refseq: NM_001159731
• Protein Refseq: NP_001153203
• UniProt ID: P28705

Reviews

05/07/2018

Aids in groundbreaking discoveries, highly recommended.

12/29/2017

Outstanding protein analysis, a research asset.

08/01/2017

Enables data-driven decisions in our research.

Q&As

How do variations in the RXRG gene affect its function and contribute to disease?

Genetic mutations in RXRG can disrupt its regulatory roles, leading to various developmental and metabolic disorders.

What is the significance of RXRG in the regulation of metabolic pathways and homeostasis?

RXRG is key in regulating lipid and glucose metabolism, playing a role in metabolic homeostasis.

What role does RXRG play in developmental processes and organogenesis?

RXRG is essential in embryonic development and organ formation, guiding cell fate decisions.

What is the primary function of RXRG in cellular signaling and gene regulation?

RXRG functions as a nuclear receptor, regulating gene expression in response to ligand binding.

What potential does RXRG have as a therapeutic target in metabolic and degenerative diseases?

Targeting RXRG in therapy offers potential in treating metabolic syndromes and degenerative diseases.

How does RXRG interact with retinoids and what is its role in vitamin A metabolism?

It interacts with retinoids to modulate vitamin A metabolism, influencing cellular differentiation and proliferation.

How does RXRG contribute to the immune system's function and response?

It influences immune function by affecting the development and differentiation of immune cells.