Recombinant Mouse Slamf8 protein(Met1-Asp231), His-tagged

• Cat.No.: Slamf8-4063M
• Product Overview: Recombinant Mouse Slamf8 protein(NP_083360.2)(Met1-Asp231), fused with C-terminal His tag, was expressed in HEK293.

Specification

• similar: Slamf8
• Alias: SLAMF8; SLAM family member 8; B lymphocyte activator macrophage expressed; B-lymphocyte activator macrophage expressed; Blame; SBBI42; 5830408F06Rik
• Source: HEK293
• Species: Mouse
• Conjugate: C-His
• Tag: C-His
• Protein length: Met1-Asp231
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• MolecularMass: The secreted recombinant mouse SLAMF8 consists of 222 amino acids and has a predicted molecular mass of 24.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmSLAMF8 is approximately 33-38 kDa due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 80 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• GeneName: Slamf8 SLAM family member 8 [ Mus musculus ]
• GeneNameWeblink: 74748
• OfficialSymbol: Slamf8
• OfficialSymbolWeblink: 74748
• GeneID: 74748
• GeneIDWeblink: 74748
• mRNARefseq: NM_029084
• mRNARefseqWeblink: NM_029084.3
• ProteinRefseqWeblink: NP_083360.2
• Synonyms: SLAMF8; SLAM family member 8; B lymphocyte activator macrophage expressed; B-lymphocyte activator macrophage expressed; Blame; SBBI42; 5830408F06Rik

Gene Information

• Synonyms: SLAMF8; SLAM family member 8; B lymphocyte activator macrophage expressed; B-lymphocyte activator macrophage expressed; Blame; SBBI42; 5830408F06Rik

Reviews

10/19/2021

Perfect for biological assays.

03/03/2021

Product works as expected.

06/20/2020

Very reliable, worth the price.

Q&As

How is SLAMF8 implicated in inflammatory and autoimmune conditions?

Dysregulation of SLAMF8 can contribute to inflammatory and autoimmune diseases.

Are there potential therapeutic interventions targeting SLAMF8?

Therapeutic interventions could potentially target SLAMF8 to modulate immune responses in various diseases.

What role does SLAMF8 play in the regulation of immune responses?

It acts as an inhibitory receptor, modulating immune cell activation and cytokine production.

What are the molecular mechanisms governing SLAMF8 activity?

SLAMF8 activity is governed by interactions with other cell surface receptors and intracellular signaling pathways.

In which immune cells is SLAMF8 predominantly expressed?

SLAMF8 is predominantly found in myeloid cells, like macrophages and dendritic cells.

What is the primary function of SLAMF8 in the immune system?

SLAMF8 regulates immune responses, particularly in myeloid cells.

How does SLAMF8 contribute to immune cell signaling?

It participates in cell-cell signaling, influencing immune cell activation and function.