Recombinant Mouse Tnfrsf4 Protein, Alexa Fluor 555 conjugated
Cat.No. : | Tnfrsf4-547MAF555 |
Product Overview : | Alexa Fluor 555 conjugated recombinant Mouse Tnfrsf4 (NP_035789.1) (Met1-Pro211) was expressed with six amino acids (LEVLFQ) at the C-terminus. |
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Description : | OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease. |
Source : | HEK293 |
Species : | Mouse |
Tag : | LEVLFQ |
Form : | Lyophilized |
Molecular Mass : | 22.1 kDa |
Protein length : | Met1-Pro211, 199 |
N-terminal Sequence Analysis : | Val 20 |
Endotoxin : | < 1.0 EU/ μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 555 via amines With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters. |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [ Mus musculus ] |
Official Symbol : | Tnfrsf4 |
Synonyms : | TNFRSF4; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor receptor superfamily member 4; OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L; |
Gene ID : | 22163 |
mRNA Refseq : | NM_011659 |
Protein Refseq : | NP_035789 |
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◆ Recombinant Protein | ||
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◆ Lysates | ||
TNFRSF4-2422HCL | Recombinant Human TNFRSF4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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