Recombinant Mouse Wee1 Protein, Myc/DDK-tagged
Cat.No. : | Wee1-6992M |
Product Overview : | Purified recombinant protein of Mouse WEE 1 homolog 1 (S. pombe) (Wee1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 71.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Wee1 WEE 1 homolog 1 (S. pombe) [ Mus musculus (house mouse) ] |
Official Symbol : | Wee1 |
Synonyms : | WEE1; WEE 1 homolog 1 (S. pombe); wee1-like protein kinase; wee1A kinase; WEE1 tyrosine kinase; Wee1A |
Gene ID : | 22390 |
mRNA Refseq : | NM_009516 |
Protein Refseq : | NP_033542 |
UniProt ID : | P47810 |
Products Types
◆ Recombinant Protein | ||
WEE1-001H | Recombinant Human WEE1 Protein, GST-tagged | +Inquiry |
WEE1-0059H | Recombinant Human WEE1 Protein (M291-K575), Tag Free | +Inquiry |
WEE1-35H | Recombinant Human WEE1 Protein (247-end), N-GST tagged | +Inquiry |
WEE1-10160M | Recombinant Mouse WEE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
WEE1-15H | Active Recombinant Human WEE1 Protein (Q36-Y432), N-GST-6×His tagged | +Inquiry |
◆ Lysates | ||
WEE1-1930HCL | Recombinant Human WEE1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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