Recombinant Rabbit AHA-1, His-tagged

• Cat.No.: AHA-1-3646R
• Product Overview: Aryl hydrocarbon receptor nuclear translocator (ARNT)

Specification

• Source: E. Coli or Yeast
• Species: Rabbit
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 790
• Purity: >90%
• Notes: Small volumes of AHA-1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: AHA-1 Arnt [ Oryctolagus cuniculus ]
• Official Symbol: AHA-1
• Synonyms: aryl hydrocarbon receptor nuclear translocatorHIF1-betaHIF-1 beta; HIF-1-beta; ARNT protein; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1-beta; dioxin receptor, nuclear translocator
• Gene ID: 100008996
• mRNA Refseq: NM_001082206
• Protein Refseq: NP_001075675
• UniProt ID: O02748
• Chromosome Location: chromosome: 13

Reviews

05/09/2022

Using this recombination protein was like having a secret weapon in the lab – it's that good!

10/01/2021

Hands down, the best protein I've ever worked with. I'm a fan!

01/19/2020

I love using this recombination protein in my research. It's so easy to work with!

03/24/2019

As a researcher, I rely on high-quality product, and this one exceeded my expectations.

03/02/2018

I'm so glad I discovered this protein; it has simplified my experiments immensely.

Q&As

What are the implications of AHA1 dysregulation in diseases?

AHA1 dysfunction has been associated with cancer, neurodegenerative disorders, and other diseases where Hsp90 client proteins play critical roles.

What are the molecular mechanisms underlying AHA1's role in regulating signal transduction pathways?

AHA1 can modulate the conformation and activity of specific signaling proteins, affecting downstream signaling events.

How does AHA1 affect the stability of oncogenic client proteins in cancer cells?

AHA1 can stabilize and promote the maturation of oncogenic client proteins, contributing to cancer cell survival and proliferation.

Describe the role of AHA1 in cellular responses to environmental stressors.

AHA1 is involved in stress response pathways, assisting in the folding and stabilization of stress-responsive proteins.

How does AHA1 facilitate the ATPase activity of Hsp90?

AHA1 binds to the middle domain of Hsp90 and stimulates its ATPase activity, accelerating the ATP hydrolysis necessary for chaperone function.

What is the role of AHA1 in protein folding and quality control mechanisms?

AHA1 assists in the correct folding of Hsp90 client proteins and also participates in the recognition and degradation of misfolded proteins.

How is the AHA1 gene transcriptionally regulated?

Transcription factors, co-activators, and epigenetic modifications can control the expression of the AHA1 gene under different cellular conditions.

How is the expression of AHA1 regulated under stress conditions?

AHA1 expression can be upregulated by various stress-inducing factors, such as heat shock, oxidative stress, or exposure to toxic compounds.

Discuss the cellular localization of AHA1 and its implications.

AHA1 is primarily localized in the cytoplasm, but it can shuttle between the cytoplasm and nucleus, influencing diverse cellular processes.

Describe the post-translational modifications that modulate AHA1 activity.

Phosphorylation and acetylation are known to regulate AHA1, influencing its interaction with Hsp90 and client proteins.