Recombinant Rat ABCC3 Protein Pre-coupled Magnetic Beads

• Cat.No.: ABCC3-60R-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Rat
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Abcc3 ATP-binding cassette, subfamily C (CFTR/MRP), member 3 [ Rattus norvegicus ]
• Official Symbol: ABCC3
• Gene ID: 140668
• mRNA Refseq: NM_080581.1
• Protein Refseq: NP_542148.1
• UniProt ID: O88563

Reviews

02/01/2023

Gifts with goods are very practical

08/06/2022

Good repeatability of experimental results

04/09/2021

High purity, good

Q&As

Can ABCC3 be used as a biomarker for cancer treatment?

Need more evidence. The expression of ABCC3 is associated with poor survival and impaired response to temozolomide. Importantly, high expression of ABCC3 is restricted to glioblastoma, with negligible levels in healthy brain tissue, and further correlates with tumor grade and stemness markers.

Does ABCC3 inhibition slows tumour progression?

Not all the tumour.Some research shows that pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

What protein can regulate ABCC3 in PDAC?

ABCC3 expression is regulated by mutant p53 via miR-34 and that the transporter drives PDAC progression via transport of the bioactive lipid lysophosphatidylinositol (LPI)

Which proteins interact with ABCC3

Lots of proteins interact with ABCC3. Such as proteins involved in transport and metabolism,ABCB1 (P-glycoprotein) and ABCG2

The Role of ABCC3 Expression in Resistance of Ovarian Cancer

ABCC3 was overexpressed in EOC tumors, but after the treatment with taxanes, its up-regulation disappeared.

Can ABCC3 be a cancer treatment target

ABCC3 has been found highly expressed in different types of cancers and is associated with poor prognosis and resistance to treatments. Some researchs provide evidences that place ABCC3 as a potential therapeutic target for improving the cancer treatment.

What is the structure of ABCC3? Do you have crystal structure result?

The crystal structure of ABCC3 has not yet been determined. However, there have been studies using cryo-electron microscopy (cryo-EM) to determine the structure of ABCC3 in complex with various ligands, such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)glutathione (DNP-SG).

What is the relationship between the expression of ABCC3 in glioma tissue and the degree of tumor development?

The expression level of the ABCC3 gene in glioma tissues was lower than that of corresponding normal brain tissues.The overall survival and disease-free survival of in the ABCC3 low-expression group was significant decreased.

What are the inhibitors of ABCC3?

MK571,Probenecid,Cepharanthine,Quinoline-based compounds

What's the functions of ABCC3

Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.

Which signal pathways regulate the expression of ABCC3?

Different cells and functions participate in different signal pathways. For example,Wnt signaling represses ABCC3 expression during colon carcinogenesis.

Is ABCC3 normally expressed in breast cancer cells?

ABCC3 is frequently amplified and overexpressed in HER2-positive breast cancer.

Which transporters are associated with colon cancer?

The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis.

Can ABCC3 transport cephalosporins?

Not sure,need more evidence.Some result shows that intestinal absorption of cefadroxil depends partly on ABCC3 and ABCC4.