Recombinant Rat ACSL6 Protein, His (Fc)-Avi-tagged

• Cat.No.: ACSL6-129R
• Product Overview: Recombinant Rat ACSL6 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Acsl6 acyl-CoA synthetase long-chain family member 6 [ Rattus norvegicus ]
• Official Symbol: ACSL6
• Gene ID: 117243
• mRNA Refseq: NM_130739.1
• Protein Refseq: NP_570095.1
• UniProt ID: P33124

Reviews

03/27/2020

I'm thrilled with the performance of this recombinant protein. It surpassed my expectations in terms of purity and yield.

10/22/2019

I'm amazed at the performance of this recombinant protein. It worked flawlessly in my assays, and the results were reproducible.

06/22/2019

The high-quality protein allowed me to achieve robust and reliable results. I'm extremely satisfied with my purchase.

06/13/2018

Overall, I highly recommend this recombinant protein and the manufacturer for their excellent product and service.

05/04/2018

The recombinant protein was delivered promptly, and the packaging ensured its stability. The purity and activity were excellent, and the product performed consistently.

Q&As

How does ACSL6 expression change with aging?

ACSL6 expression has been shown to decrease with age, which may contribute to age-related metabolic dysfunction.

How does ACSL6 affect insulin sensitivity?

Studies have shown that increased ACSL6 expression in adipose tissue is associated with improved insulin sensitivity and decreased risk of developing type 2 diabetes.

What is the tissue distribution of ACSL6 expression?

ACSL6 is expressed in a variety of tissues, including adipose tissue, liver, muscle, and heart.

What is the role of ACSL6 in the brain?

ACSL6 is involved in the uptake and utilization of fatty acids in the brain, which plays a critical role in maintaining brain function.

How is the ACSL6 protein regulated at the transcriptional level?

ACSL6 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.

How is ACSL6 expression regulated in response to changes in cellular energy status?

ACSL6 expression is regulated by AMPK, a key cellular energy sensor that activates ACSL6 transcription in response to low energy status.

What is the role of the C-terminal acyl-CoA synthetase domain of ACSL6?

The C-terminal domain of ACSL6 is responsible for the catalytic activity of the enzyme, which involves the activation of long-chain fatty acids by attaching them to coenzyme A.

What is the role of ACSL6 in lipid droplet formation?

ACSL6 is involved in the synthesis and storage of triacylglycerols in lipid droplets, which plays a critical role in maintaining lipid homeostasis.

How is ACSL6 involved in mitochondrial function?

ACSL6 is involved in the transport of fatty acids into the mitochondria, which is necessary for mitochondrial energy production.

How does the AMP-binding domain of ACSL6 regulate enzyme activity?

The AMP-binding domain of ACSL6 binds to AMP, which can activate the enzyme and increase its activity.